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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
StAR Antibody Adrenal Marker / Steroidogenic Acute Regulatory Protein Antibody [clone SARP1-1] (V3886)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3886-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
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V3886-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3886SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | SARP1-1 |
| Purity | Protein G affinity chromatography |
| UniProt | P49675 |
| Localization | Cytoplasmic (mitochondrial) |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This StAR antibody is available for research use only. |
|
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Steroidogenic Acute Regulatory Protein (StAR), encoded by the STARD1 gene, is a mitochondrial cholesterol transport protein that plays a central role in steroid hormone biosynthesis. StAR Antibody Adrenal Marker / Steroidogenic Acute Regulatory Protein Antibody (clone SARP1-1) is a mouse monoclonal antibody developed for detection of this key steroidogenic regulatory protein in endocrine tissues. StAR mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane, an essential step that initiates steroid hormone synthesis. Because this cholesterol transport event represents the rate-limiting step in steroidogenesis, StAR is widely studied as a marker of steroid-producing endocrine cells.
Within the adrenal gland, StAR expression is highly enriched in steroidogenic cells of the adrenal cortex, where glucocorticoids, mineralocorticoids, and adrenal androgens are synthesized. Immunohistochemistry staining with a StAR antibody typically highlights cells of the adrenal cortical layers while the adrenal medulla shows little or no staining. This distinct tissue distribution makes StAR a valuable adrenal marker for identifying steroidogenic cortical cells and distinguishing them from medullary chromaffin cells that produce catecholamines rather than steroid hormones.
The adrenal cortex is organized into functional zones that produce different steroid hormones, including the zona glomerulosa, zona fasciculata, and zona reticularis. These cortical zones rely on mitochondrial cholesterol transport to initiate hormone synthesis, and StAR protein expression reflects the steroidogenic activity of these endocrine cells. Detection of Steroidogenic Acute Regulatory Protein therefore provides insight into adrenal steroidogenesis and the regulation of cholesterol transport within mitochondria of steroid-producing cells.
StAR expression is also observed in other steroidogenic tissues including testicular Leydig cells and ovarian theca and luteal cells. These endocrine cells require efficient mitochondrial cholesterol transport to sustain synthesis of sex steroids such as testosterone, progesterone, and estrogen. As a result, Steroidogenic Acute Regulatory Protein is widely used in endocrine research to examine steroidogenic differentiation and hormone biosynthesis pathways in adrenal and gonadal tissues.
Because StAR expression closely reflects the steroidogenic capacity of endocrine cells, antibodies targeting this protein are frequently used to investigate adrenal cortex biology and steroid hormone production. Clone SARP1-1 provides a mouse monoclonal antibody reagent designed to detect Steroidogenic Acute Regulatory Protein in studies examining adrenal steroidogenesis, mitochondrial cholesterol transport, and endocrine tissue organization.
Optimal dilution of the StAR Antibody Adrenal Marker should be determined by the researcher.
A portion of amino acids 39-108 from the human protein was used as the immunogen for this StAR Antibody Adrenal Marker.
Store the StAR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
StAR antibody, Steroidogenic acute regulatory protein antibody, STARD1 antibody, STAR protein antibody, Cholesterol transport protein StAR antibody
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