- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SST Antibody / Somatostatin [clone 31S68] (FY12635)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12635 | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA | 100 ul | 449 |
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Somatostatin (SST) is a regulatory peptide hormone encoded by the SST gene and widely expressed in neuroendocrine tissues, including pancreatic islets, gastrointestinal mucosa, and neurons of the central nervous system. SST Antibody / Somatostatin (clone 31S68) recognizes this inhibitory peptide precursor and supports research focused on endocrine signaling, neuronal regulation, and pancreatic hormone control. Somatostatin belongs to a family of inhibitory neuropeptides that regulate the secretion of multiple hormones and neurotransmitters through interaction with somatostatin receptors. Within the pancreas, somatostatin is primarily produced by delta cells of the islets of Langerhans, where it modulates secretion of insulin and glucagon to maintain metabolic homeostasis.
Somatostatin is initially synthesized as the precursor protein preprosomatostatin, which undergoes proteolytic processing to generate the biologically active peptide hormones somatostatin-14 and somatostatin-28. These peptides function through a group of G protein-coupled somatostatin receptors that mediate inhibitory signaling pathways controlling endocrine secretion, neuronal activity, and cellular proliferation. Because of this regulatory role, SST expression is frequently studied in endocrine pancreas biology, gastrointestinal hormone signaling, and neuroendocrine tumor research.
In addition to classical somatostatin peptides, the SST precursor also gives rise to neuronostatin, a smaller peptide derived from the same preprohormone. Neuronostatin has been reported to show biological activity distinct from traditional somatostatin receptor signaling and is expressed in hypothalamic neurons and pancreatic tissues. This expanded precursor biology has broadened interest in Somatostatin antibody reagents, as researchers may investigate both canonical somatostatin signaling and alternative peptide functions derived from the same gene product.
Somatostatin expression is commonly observed in pancreatic delta cells, gastrointestinal endocrine cells, and subsets of neurons throughout the brain and peripheral nervous system. Due to this distribution, antibodies against SST are widely used in studies examining endocrine cell identity, neuropeptide signaling pathways, and neuroendocrine tissue organization. The recombinant rabbit monoclonal clone 31S68 provides a reagent for detecting somatostatin expression in research investigating pancreatic hormone regulation, neuronal peptide biology, and broader neuroendocrine regulatory mechanisms.
Optimal dilution of the SST antibody should be determined by the researcher.
A synthesized peptide derived from human Somatostatin 28 was used as the immunogen for the SST antibody.
Store the SST antibody at -20oC.
Somatostatin antibody, SST antibody, Preprosomatostatin antibody, Somatotropin release inhibiting factor antibody, Growth hormone release inhibiting factor antibody
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