- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SREBP2 Antibody / SREBF2 (RQ6804)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ6804 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q12772 |
| Localization | Cytoplasmic, nuclear |
| Applications | Western Blot : 1-2ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This SREBP2 antibody is available for research use only. |
|
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SREBP2 antibody targets sterol regulatory element-binding protein 2, encoded by the SREBF2 gene. Sterol regulatory element-binding protein 2 is a membrane-bound transcription factor that plays a central role in cholesterol homeostasis by regulating genes involved in cholesterol biosynthesis and uptake. SREBP2 belongs to the SREBP family of basic helix-loop-helix leucine zipper transcription factors and is synthesized as an inactive precursor anchored in the endoplasmic reticulum membrane.
Functionally, SREBP2 is activated through regulated proteolytic cleavage in response to cellular sterol depletion. Upon activation, the N-terminal transcriptionally active fragment translocates to the nucleus, where it binds sterol regulatory elements in the promoters of target genes such as HMGCR, HMGCS1, and LDLR. Through this mechanism, SREBP2 coordinates transcriptional programs that maintain intracellular cholesterol levels. A SREBP2 antibody supports studies focused on lipid metabolism, transcriptional regulation, and sterol-sensitive signaling pathways.
SREBF2 expression is widespread, reflecting the fundamental requirement for cholesterol regulation in most cell types. Subcellular localization is dynamic, with the full-length precursor localized to the endoplasmic reticulum and Golgi membranes, while the processed active form localizes to the nucleus. This dual localization pattern reflects the tightly controlled activation process that links membrane lipid status to nuclear gene expression.
From a disease relevance perspective, dysregulation of SREBP2 signaling has been implicated in metabolic disorders, cardiovascular disease, and cancer, where altered cholesterol metabolism can support abnormal cell growth and survival. At the molecular level, sterol regulatory element-binding protein 2 contains a basic helix-loop-helix leucine zipper DNA-binding domain and regulatory regions that control sterol-dependent activation. SREBP2 antibody reagents support research applications examining lipid metabolic pathways and transcriptional responses to cholesterol availability, with NSJ Bioreagents providing reagents intended for research use.
Optimal dilution of the SREBP2 antibody should be determined by the researcher.
Recombinant human protein (amino acids R371-L409) was used as the immunogen for the SREBP2 antibody.
After reconstitution, the SREBP2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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