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Home >> Antibodies >> SQSTM1 Antibody

SQSTM1 Antibody (F47389)

  Catalog No Formulation Size Price (USD)  
Image F47389-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F47389-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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SQSTM1 antibody western blot analysis in HeLa lysate. Observed molecular weight ~62 kDa.
Availability 1-3 business days
Species Reactivity Human
Predicted Reactivity Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q13501
Applications Western blot : 1:1000
Limitations This SQSTM1 antibody is available for research use only.
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Description

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

Application Notes

Titration of the SQSTM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 383-409 from the human protein was used as the immunogen for this SQSTM1 antibody.

Storage

Aliquot the SQSTM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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