- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SP110 Antibody / SP110 nuclear body protein (FY13102)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13102 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
SP110 antibody detects SP110 nuclear body protein, a transcriptional coactivator and nuclear body component involved in immune response regulation and chromatin organization. The UniProt recommended name is SP110 nuclear body protein (SP110). This nuclear protein functions as part of the promyelocytic leukemia (PML) nuclear body complex, participating in transcriptional control, apoptosis, and antiviral defense.
Functionally, SP110 antibody identifies a 688-amino-acid protein that acts as a coactivator for nuclear hormone receptors and NF-kappaB-dependent transcription. SP110 regulates gene expression in macrophages and lymphocytes, enhancing interferon-stimulated gene transcription and pathogen defense. It also contributes to chromatin remodeling and transcriptional repression of inflammatory genes through PML-associated nuclear bodies.
The SP110 gene is located on chromosome 2q37.1 and is highly expressed in hematopoietic tissues. SP110 expression is induced by interferon signaling and pathogen exposure, positioning it as a regulator of innate and adaptive immune responses. Its nuclear localization and coactivator activity support immune system homeostasis and pathogen resistance.
Pathologically, SP110 gene mutations are associated with hepatic veno-occlusive disease with immunodeficiency (VODI), a rare autosomal recessive disorder causing liver failure and impaired immunity. Abnormal expression of SP110 has also been linked to autoimmune conditions and susceptibility to intracellular infections such as tuberculosis. Research with SP110 antibody supports studies in nuclear organization, immune regulation, and transcriptional control.
SP110 antibody is suitable for western blotting, immunofluorescence, and immunohistochemistry to detect nuclear body components and transcriptional cofactors. NSJ Bioreagents offers SP110 antibody reagents validated for use in immunology, transcription, and chromatin regulation research.
Structurally, SP110 contains N-terminal SAND and coiled-coil domains that mediate DNA and protein binding, as well as nuclear localization signals that target it to PML bodies. This antibody enables analysis of SP110s role in transcriptional activation and immune regulation under interferon signaling conditions.
Optimal dilution of the SP110 antibody should be determined by the researcher.
E.coli-derived human SP110 recombinant protein (Position: M1-E615) was used as the immunogen for the SP110 antibody.
After reconstitution, the SP110 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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