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Home >> Antibodies >> SOX9 Antibody

SOX9 Antibody [clone SOX9/2104] (V8965)

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  Catalog No Formulation Size Price (USD)  
Image V8965-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 559
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V8965-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 259
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V8965SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 559
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Immunohistochemistry analysis of SOX9 antibody in human pancreatic tissue. FFPE human pancreas sections show strong HRP-DAB brown nuclear staining in ductal epithelial cells and scattered epithelial cell populations, consistent with the nuclear localization of SOX9 as a transcription factor. Acinar cells demonstrate minimal background staining, while stromal components are largely negative. The staining pattern highlights SOX9 expression within pancreatic ductal structures and progenitor-associated epithelial compartments. Heat induced epitope retrieval was performed in 10 mM Tris with 1 mM EDTA, pH 9.0, by boiling for 20 minutes followed by cooling prior to antibody incubation.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Host Mouse
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b
Clone Name SOX9/2104
Purity Protein A/G affinity
UniProt P48436
Localization Nuclear
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This SOX9 antibody is available for research use only.
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Description

SOX9 Antibody recognizes SOX9, a nuclear transcription factor encoded by the SOX9 gene and widely known as SRY-box 9. SOX9 is a member of the SRY-related HMG-box family and functions as a key regulator of lineage specification, differentiation, and tissue remodeling. SOX9 Antibody detects a nuclear protein that orchestrates gene expression programs during embryonic development and adult tissue homeostasis.

In chondrogenesis, SOX9 is required for commitment of mesenchymal cells to the chondrocyte lineage and for maintenance of cartilage-specific gene expression. The protein activates structural genes necessary for extracellular matrix assembly and cartilage integrity. Deficiency or mutation of SOX9 results in skeletal abnormalities and developmental syndromes.

SOX9 also plays a vital role in gonadal development and is required for proper testis formation. In epithelial tissues such as pancreas, liver, and intestine, SOX9 marks progenitor compartments and participates in regenerative responses following injury. Its regulated expression reflects dynamic control of developmental and repair processes.

In oncology research, SOX9 has been implicated in tumor cell survival, invasion, and maintenance of stem-like characteristics. Nuclear localization remains a defining feature of SOX9 detection in tissue-based assays.

SOX9 Antibody is suitable for research applications examining cartilage biology, developmental regulation, epithelial progenitor populations, and disease-associated transcriptional changes.

Application Notes

Optimal dilution of the SOX9 antibody should be determined by the researcher.

Immunogen

A portion of amino acids 393-508 was used as the immunogen for the SOX9 antibody.

Storage

Aliquot the SOX9 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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