- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Related Products
|
SOX10 antibody is a key reagent for studying the transcription factor SOX10, which belongs to the SRY related HMG box family. SOX10 is expressed in neural crest derived lineages, where it directs the development of melanocytes, Schwann cells, and oligodendrocytes. Its function is essential for cell fate determination, differentiation, and survival. Because of its central roles, SOX10 is studied in developmental biology, neuroscience, and oncology.
SOX10 functions as a DNA binding transcription factor that regulates genes involved in glial differentiation, myelination, and pigment cell development. By binding to promoter and enhancer regions, it activates or represses expression of genes critical for lineage specification. Mutations in SOX10 are associated with disorders such as Waardenburg syndrome and Hirschsprung disease, underscoring its biological significance.
The SOX10 antibody clone SOX10/991 provides specific detection of this transcription factor. Clone SOX10/991 has been applied to studies of neural crest biology, glial development, and melanocyte differentiation. Its nuclear localization pattern enables clear identification of SOX10 positive cells in tissues and experimental systems. The reproducibility of this clone makes it a reliable reagent for both research and diagnostic contexts.
In pathology, SOX10 is an important marker for identifying melanoma, schwannoma, and other neural crest derived tumors. Research using clone SOX10/991 has advanced classification of these cancers and improved diagnostic accuracy. In neuroscience, the antibody supports studies into myelination and oligodendrocyte function, providing insights into demyelinating diseases such as multiple sclerosis.
NSJ Bioreagents provides this SOX10 antibody to support investigations in developmental biology, neuroscience, and oncology. Alternate names used for this protein include transcription factor SOX10 antibody, SRY related HMG box 10 antibody, Waardenburg syndrome gene antibody, and Schwann cell transcription regulator antibody, reflecting the variety of ways SOX10 is referenced in scientific research.
Optimal dilution of the SOX10 antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Amino acids 115-269 of the human protein were used as the immunogen for the SOX10 antibody.
Store the SOX10 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.