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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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SOX10 antibody recognizes SRY-box transcription factor 10, a nuclear DNA-binding protein encoded by the SOX10 gene and a member of the SOX family of high mobility group box transcription factors. SOX10 contains a conserved HMG-box domain that enables sequence-specific DNA interaction and bending of DNA to facilitate transcriptional complex assembly. This nuclear localization is a defining feature of SOX10 expression and is consistently observed when using a SOX10 antibody in tissue-based assays. SOX10 plays a critical role in embryonic neural crest development, where it regulates lineage commitment and differentiation of melanocytes, Schwann cells, peripheral glia, and components of the enteric nervous system. During melanocyte development, SOX10 directly influences MITF transcription and downstream pigmentation pathways, supporting melanin synthesis and melanocyte survival. In peripheral nerve biology, SOX10 participates in Schwann cell maturation and myelination programs, interacting with signaling pathways including Wnt, Notch, and neuregulin-mediated mechanisms. In adult tissues, SOX10 expression is largely restricted to melanocytes within the basal epidermis and hair follicles, as well as Schwann cells in peripheral nerves, reflecting its neural crest origin. This restricted distribution makes SOX10 antibody a valuable marker for identifying neural crest-derived cell populations. In oncology research, SOX10 expression is frequently detected in melanoma, peripheral nerve sheath tumors, and clear cell sarcoma, where its nuclear staining pattern assists in confirming melanocytic or neural crest lineage. SOX10 has also been reported in subsets of triple-negative breast carcinoma and other tumors with basal-like or stem-like features. Dysregulation of SOX10 may contribute to tumor progression, cellular plasticity, and invasive behavior. Because of its strong nuclear staining and lineage specificity, SOX10 antibody is suitable for detecting SOX10 expression in immunohistochemistry and related research assays, supporting studies in developmental biology, neurobiology, dermatopathology, and cancer research.
Optimal dilution of the SOX10 antibody should be determined by the researcher.
A portion of amino acids 90-179 was used as the immunogen for the SOX10 antibody.
Aliquot the SOX10 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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