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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SOX10 Rabbit Polyclonal Antibody (F49359)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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F49359-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 439 | |
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F49359-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 205 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Predicted Reactivity | Rat, Pig |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity |
| UniProt | P56693 |
| Localization | Nuclear, cytoplasmic |
| Applications | Western Blot : 1:2000 IHC (Paraffin) : 1:10-1:50 |
| Limitations | This SOX10 Rabbit Polyclonal Antibody is available for research use only. |
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SOX10 Rabbit Polyclonal Antibody recognizes SOX10, a nuclear transcription factor belonging to the SRY-related high-mobility-group (HMG) box family of DNA-binding proteins. Also known as SRY-Box Transcription Factor 10, SOX10 regulates gene expression programs involved in neural crest development, cellular differentiation, and nervous system formation. The protein contains a conserved HMG DNA-binding domain that enables interactions with regulatory DNA sequences. SOX10 is particularly important in melanocytes, Schwann cells, oligodendrocytes, and other specialized cell populations derived from neural crest progenitors.
During embryonic development, SOX10 helps regulate the survival, migration, and differentiation of neural crest-derived cells. It cooperates with other transcription factors to establish distinct cellular lineages, including melanocytes and peripheral glial cells. In melanocyte development, SOX10 promotes expression of microphthalmia-associated transcription factor (MITF), a major regulator of pigmentation and melanocyte differentiation. Disruption of this regulatory pathway can impair melanocyte development and contribute to pigmentation abnormalities.
SOX10 also plays essential roles in the development and maintenance of the nervous system. In Schwann cells, it coordinates transcriptional programs required for peripheral nerve maturation and myelin formation. Within the central nervous system, SOX10 participates in oligodendrocyte differentiation and regulates genes associated with myelination. These functions make SRY-Box Transcription Factor 10 an important marker for investigating glial development, neural crest biology, and nervous system organization.
In cancer research, SOX10 is widely studied as a marker of melanocytic differentiation. Many melanomas exhibit nuclear SOX10 expression, making the protein useful for investigating melanocytic tumors and their biological characteristics. SOX10 is also expressed in peripheral nerve sheath tumors and certain breast and salivary gland carcinomas. Because its expression is not restricted to melanoma, immunohistochemical findings must be interpreted alongside tissue morphology and additional lineage-associated markers.
Pathogenic variants in the SOX10 gene are associated with neurocristopathies, including Waardenburg syndrome and Waardenburg-Shah syndrome. These disorders may involve pigmentation abnormalities, hearing impairment, and intestinal aganglionosis, reflecting the importance of SOX10 in neural crest-derived tissues. Altered SOX10 expression is also investigated in melanoma progression, tumor cell plasticity, and changes in differentiation state.
A SOX10 Rabbit Polyclonal Antibody from NSJ Bioreagents supports research investigating SRY-Box Transcription Factor 10 expression, neural crest differentiation, glial development, melanocytic lineage identity, and SOX10-associated disorders.
For a recombinant monoclonal alternative targeting the same transcription factor, see our SOX10 Antibody rSOX10/1074 (V3563), featuring WB, IHC, and protein microarray validation.
Titration of the SOX10 Rabbit Polyclonal Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 231-259 from the human protein was used as the immunogen for this SOX10 Rabbit Polyclonal Antibody.
Aliquot the SOX10 Rabbit Polyclonal Antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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