- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SOD1 Antibody / Superoxide Dismutase 1 (R31855)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R31855 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P00441 |
| Localization | Cytoplasmic, Nuclear |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Flow Cytometry : 1-3ug/million cells |
| Limitations | This SOD1 antibody is available for research use only. |
|
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SOD1 (Superoxide Dismutase 1) is a critical antioxidant enzyme that protects cells from oxidative stress by catalyzing the conversion of superoxide radicals into oxygen and hydrogen peroxide. This cytoplasmic enzyme is widely expressed in human tissues and plays a central role in maintaining redox balance, cellular homeostasis, and protection against free radical-mediated damage. A SOD1 antibody is commonly used in research to investigate oxidative stress pathways, neurodegeneration, and cellular defense mechanisms.
Beyond its fundamental enzymatic function, SOD1 has been closely studied for its involvement in human disease. Mutations in the SOD1 gene are linked to familial forms of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disorder affecting motor neurons. Research using a SOD1 antibody has helped to characterize misfolded protein aggregates, altered enzyme activity, and associated cytotoxic mechanisms in ALS models. This makes SOD1 a widely studied biomarker in both basic neuroscience and translational research.
SOD1 is also relevant in cardiovascular and metabolic disorders, where oxidative stress contributes to pathology. In addition, its role in aging and longevity is actively explored, as regulation of reactive oxygen species is fundamental to cellular survival. The ability of SOD1 to balance oxidative environments has made it a valuable protein for understanding the molecular underpinnings of health and disease.
NSJ Bioreagents provides a high-quality SOD1 antibody validated for multiple applications, including western blotting, immunohistochemistry, and immunofluorescence. By using a reliable SOD1 antibody from NSJ Bioreagents, researchers can advance their studies on oxidative stress, neurodegeneration, and cellular defense.
Optimal dilution of the SOD1 antibody should be determined by the researcher.
Amino acids RTLVVHEKADDLGKGGNEESTKTGNAGSRLA of human SOD1 were used as the immunogen for the SOD1 antibody.
After reconstitution, the SOD1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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