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Home >> Antibodies >> SNRPN Antibody

SNRPN Antibody [clone 6F12] (RQ4917)

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  Catalog No Formulation Size Price (USD)  
Image RQ4917 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 329
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Flow cytometry testing of human A549 cells with SNRPN antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= SNRPN antibody.
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Flow cytometry testing of human A549 cells with SNRPN antibody at 1ug/million cells (blocked with goat sera); Red=cells alone, Green=isotype control, Blue= SNRPN antibody.
Western blot testing of 1) human U-87 MG, 2) human Caco-2, 3) rat brain and 4) mouse brain lysate with SNRPN antibody. Predicted molecular weight ~26 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b
Clone Name 6F12
Purity Purified
Buffer Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
UniProt P63162
Applications Western blot : 0.5-1ug/ml
Flow cytometry : 1-3ug/million cells
Limitations This SNRPN antibody is available for research use only.
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Description

SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N), also called SMN, is a bicistronic imprinted gene that encodes 2 polypeptides, the SmN splicing factor, which is involved in RNA processing, and the SNRPN upstream reading frame (SNURF) polypeptide. The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. SNRPN also encodes a long alternatively spliced transcript containing several small nucleolar RNAs (snoRNAs) and extends downstream to partially overlap the UBE3A gene in the antisense orientation. PWS arises from loss of function of genes in this region expressed exclusively from the paternal chromosome, suggesting that SNRPN may play a role in its etiology. The SNRPN gene is mapped on 15q11.2. Analysis of maternal DNA and of SNRPN cDNA confirmed that the maternal allele is not expressed in fetal brain and heart. Deletions in the transcription unit of the imprinted SNRPN gene occur in patients who have PWS or Angelman syndrome because of a parental imprint switch failure in this chromosomal domain.

Application Notes

Optimal dilution of the SNRPN antibody should be determined by the researcher.

Immunogen

Amino acids QHIDYRMRCILQDGRIFIGTFKAFDKHMN from the human protein were used as the immunogen for the SNRPN antibody.

Storage

After reconstitution, the SNRPN antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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