- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SMURF2 Antibody / E3 Ubiquitin Ligase Antibody (RQ5537)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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RQ5537 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q9HAU4 |
| Applications | Western Blot : 0.5-1ug/ml Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This SMURF2 Antibody / E3 Ubiquitin Ligase Antibody is available for research use only. |
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SMURF2 Antibody / E3 Ubiquitin Ligase Antibody recognizes SMURF2, a HECT-domain E3 ubiquitin ligase that regulates protein stability through ubiquitin-dependent signaling pathways. As a member of the NEDD4 family of E3 ubiquitin ligases, SMURF2 catalyzes the transfer of ubiquitin to specific substrate proteins, directing their degradation or modulating their cellular activity. SMURF2 was originally identified as a regulator of transforming growth factor beta (TGF-beta) signaling through ubiquitination of SMAD proteins and their associated signaling components. Since then, it has emerged as a multifunctional regulator of cell proliferation, differentiation, senescence, DNA damage responses, chromatin organization, and tumor suppression.
SMURF2 controls numerous signaling pathways by targeting proteins involved in TGF-beta, bone morphogenetic protein (BMP), Wnt, Hedgehog, and additional developmental and stress-response pathways. Through selective ubiquitination of receptors, transcription factors, and signaling adaptors, SMURF2 helps maintain appropriate signal intensity and duration. Beyond its cytoplasmic functions, SMURF2 also participates in regulation of genome stability by influencing chromatin remodeling, histone ubiquitination, and DNA repair. These activities contribute to maintenance of normal cellular homeostasis while limiting inappropriate proliferation and oncogenic transformation.
Altered SMURF2 expression or activity has been associated with numerous cancers, fibrotic disorders, inflammatory diseases, and age-related pathologies. Depending on cellular context, SMURF2 may function as either a tumor suppressor or an oncogenic regulator by controlling the stability of proteins involved in cell cycle progression, apoptosis, epithelial-to-mesenchymal transition, and metastatic signaling. SMURF2 has also been implicated in cellular senescence, stem cell biology, and tissue remodeling, making it an important target for studies of signal transduction, ubiquitin biology, and therapeutic intervention.
SMURF2 is highly conserved among vertebrates and continues to be extensively investigated for its central role in ubiquitin-mediated regulation of intracellular signaling. Its ability to coordinate multiple signaling networks places it at the intersection of protein quality control, developmental biology, and cancer research. A SMURF2 Antibody is a valuable research tool for investigating E3 ubiquitin ligases, protein ubiquitination, TGF-beta signaling, signal transduction, and tumor biology.
Explore additional research tools for oncogenic signaling, cell regulation, and tumor biology on our Cancer Marker Antibodies page.
Optimal dilution of the SMURF2 Antibody / E3 Ubiquitin Ligase Antibody should be determined by the researcher.
A human recombinant protein (amino acids W303-Q387) was used as the immunogen for the SMURF2 antibody.
After reconstitution, the SMURF2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
SMURF2 antibody, E3 Ubiquitin Ligase antibody, SMAD Specific E3 Ubiquitin Protein Ligase 2 antibody, SMAD Ubiquitination Regulatory Factor 2 antibody
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