- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Smooth Muscle Actin Antibody / ACTA2 [clone rACTA2/1625] (V9287)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V9287-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V9287-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 | 259 | |
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V9287SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human (broad species reactivity predicted) |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rACTA2/1625 |
| Purity | Protein A/G affinity |
| UniProt | P62736 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Smooth Muscle Actin antibody is available for research use only. |
|
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Smooth Muscle Actin antibody recognizes Alpha smooth muscle actin, a cytoskeletal contractile protein encoded by the human ACTA2 gene located on chromosome 10q23.31. Alpha smooth muscle actin is a major component of the actin filament network in vascular smooth muscle cells and is predominantly localized in the cytoplasm, where it forms filamentous structures that contribute to cellular contractility and structural integrity. Smooth Muscle Actin antibody targets a protein widely used as a marker of smooth muscle differentiation and myofibroblast activation.
ACTA2 belongs to the actin family of highly conserved proteins that polymerize to form microfilaments. Alpha smooth muscle actin is specifically enriched in vascular smooth muscle cells, pericytes, and activated myofibroblasts. It plays a critical role in maintaining vascular tone, regulating blood pressure, and mediating wound contraction. In normal physiology, ACTA2 expression supports contractile function in arteries and other smooth muscle-containing tissues. During tissue injury and fibrosis, fibroblasts can acquire a myofibroblast phenotype characterized by increased ACTA2 expression and enhanced contractile capability.
Altered ACTA2 expression has been associated with a range of pathological conditions. Mutations in ACTA2 are linked to familial thoracic aortic aneurysm and dissection, reflecting the importance of smooth muscle actin in vascular wall stability. Increased Alpha smooth muscle actin expression is also observed in fibrotic diseases and within the tumor microenvironment, where cancer-associated fibroblasts express ACTA2 and contribute to tumor progression and stromal remodeling. Because of its role in contractile differentiation, Smooth Muscle Actin antibody is frequently used to identify smooth muscle cells and activated stromal components in histological studies.
Smooth Muscle Actin antibody is suitable for detecting Alpha smooth muscle actin expression in research focused on vascular biology, fibrosis, wound healing, and tumor stroma analysis. Recombinant monoclonal clone rACTA2/1625 is produced using defined expression systems to promote lot-to-lot consistency and reliable performance in research applications.
Optimal dilution of the Smooth Muscle Actin antibody should be determined by the researcher.
N-Terminal decapeptide of alpha smooth muscle isoform of actin was used as the immunogen for the Smooth Muscle Actin antibody.
Aliquot the Smooth Muscle Actin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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