- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SMARCA4 Antibody / BRG1 [clone BRG1/8805R] (V4588)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4588-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4588-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4588SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | BRG1/8805R |
| Purity | Protein A/G affinity |
| UniProt | P51532 |
| Localization | Nucleus |
| Applications | ELISA (Order BSA-free Format For Coating) : Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This SMARCA4 antibody is available for research use only. |
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SMARCA4 (BRG1) is an ATP-dependent chromatin remodeling enzyme that functions as a catalytic subunit of the SWI/SNF chromatin remodeling complex and regulates transcription through nucleosome repositioning and chromatin accessibility. SMARCA4 Antibody / BRG1 (clone BRG1/8805R) recognizes the BRG1 protein encoded by the SMARCA4 gene and is produced as a recombinant rabbit monoclonal antibody designed for consistent detection of this chromatin remodeling ATPase. BRG1, also known as Brahma related gene 1, is a large nuclear protein that plays a key role in transcriptional regulation, cellular differentiation, and tumor suppression pathways through its ability to regulate chromatin structure.
BRG1 localizes predominantly to the cell nucleus where it functions within the SWI/SNF complex to remodel chromatin and control access of transcription factors to regulatory DNA elements. Through ATP hydrolysis, the BRG1 ATPase drives repositioning of nucleosomes, allowing activation or repression of gene expression programs involved in development, cell cycle regulation, and cellular differentiation. Because of this central regulatory role, SMARCA4 is widely studied in molecular biology and cancer research investigating chromatin remodeling mechanisms and transcriptional control.
Clone BRG1/8805R is developed as a recombinant rabbit monoclonal antibody, combining the high affinity binding characteristics of rabbit monoclonal antibodies with the consistency of recombinant antibody production. Recombinant rabbit monoclonal antibodies are generated from defined antibody sequences expressed in controlled recombinant systems, which helps maintain reproducible antibody performance and stable epitope recognition across production lots. This recombinant rabbit monoclonal antibody format supports reliable detection of the BRG1 protein in research studies examining chromatin remodeling complexes and transcriptional regulatory pathways.
SMARCA4 plays an important role in tumor suppression and alterations in BRG1 expression have been reported in multiple malignancies. Loss or mutation of SMARCA4 has been observed in lung carcinoma, thoracic sarcoma, ovarian small cell carcinoma of hypercalcemic type, and other tumor types associated with disruption of SWI/SNF chromatin remodeling components. Because of these biological roles, BRG1 detection is commonly used to investigate chromatin remodeling defects and to study tumor-associated alterations in SWI/SNF complex function.
SMARCA4 Antibody / BRG1 (clone BRG1/8805R) therefore provides a recombinant rabbit monoclonal antibody reagent for detecting the BRG1 chromatin remodeling ATPase in studies focused on transcriptional regulation, chromatin remodeling biology, and SWI/SNF complex function.
Optimal dilution of the SMARCA4 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the SMARCA4 antibody.
Aliquot the SMARCA4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
BRG1 antibody, SMARCA4 antibody, Brahma related gene 1 antibody, SWI/SNF ATP dependent chromatin remodeler antibody
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