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- Tel: 858.663.9055
- Email: info@nsjbio.com
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SMAD2 is a receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. [UniProt]
Titration of the SMAD2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
This SMAD2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 106-140 amino acids from the N-terminal region of human SMAD2.
Aliquot the SMAD2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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