- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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SLC8A1 Antibody / NCX1 Antibody, clone 18S76, recognizes the sodium-calcium exchanger encoded by the SLC8A1 gene, one of the major membrane transport proteins responsible for maintaining intracellular calcium homeostasis. SLC8A1 is expressed in numerous tissues, with particularly high levels in the heart, brain, kidney, and vascular smooth muscle. By exchanging intracellular calcium for extracellular sodium, NCX1 regulates cytosolic calcium concentrations that control muscle contraction, electrical activity, secretion, and cell signaling. As a recombinant rabbit monoclonal antibody, clone 18S76 provides a highly specific reagent for investigating SLC8A1 expression in normal physiology and disease models.
SLC8A1 plays an essential role in cardiac excitation-contraction coupling by removing calcium from cardiomyocytes during relaxation. Depending on membrane potential and ionic gradients, the exchanger can also mediate calcium influx, allowing it to participate in dynamic regulation of calcium signaling under physiological and pathological conditions. Beyond the cardiovascular system, NCX1 contributes to neuronal calcium regulation, synaptic function, vascular smooth muscle contraction, and renal physiology. SLC8A1 Antibody is therefore widely used to study membrane transporter biology, calcium-dependent signaling, and tissue-specific regulation of ion homeostasis.
Altered expression or activity of SLC8A1 has been implicated in heart failure, cardiac hypertrophy, ischemia-reperfusion injury, arrhythmias, hypertension, stroke, and neurodegenerative disorders. Because calcium dysregulation contributes to numerous human diseases, NCX1 has become an important target for studies investigating disease mechanisms and therapeutic interventions that restore normal calcium balance. Researchers frequently evaluate changes in SLC8A1 abundance, localization, and regulation to better understand how disturbed sodium-calcium exchange influences cellular survival and tissue function.
SLC8A1 is commonly analyzed by Western blotting, immunohistochemistry, immunofluorescence, flow cytometry, immunoprecipitation, and related protein detection methods using heart, brain, and cultured cells expressing endogenous protein. Clone 18S76 provides a recombinant rabbit monoclonal option for sensitive and reproducible detection of this important membrane transporter. A SLC8A1 Antibody is a valuable research tool for detecting endogenous NCX1 expression and investigating sodium-calcium exchange, calcium homeostasis, cardiac physiology, membrane transporter biology, and neuronal signaling.
Learn more about NCX1 biology and its role in calcium transport by visiting our NCX1 Antibody / Sodium Calcium Exchanger Antibody page.
Optimal dilution of the SLC8A1 Antibody / NCX1 Antibody should be determined by the researcher.
A synthesized peptide derived from human Sodium/calcium exchanger 1 protein was used as the immunogen for the SLC8A1 antibody.
Store the SGCD Antibody at -20oC for one year, or at 4oC for one month.
SLC8A1 antibody, NCX1 antibody, Sodium Calcium Exchanger 1 antibody, Solute Carrier Family 8 Member A1 antibody
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