- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SLC17A6 Antibody / VGLUT2 / Vesicular glutamate transporter 2 (FY12581)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12581 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
Related Products
|
SLC17A6 antibody detects Vesicular glutamate transporter 2 (VGLUT2), a membrane protein responsible for packaging the excitatory neurotransmitter glutamate into synaptic vesicles. SLC17A6 plays a central role in excitatory neurotransmission throughout the central nervous system, determining the quantal content of glutamatergic synapses. The SLC17A6 antibody is widely used in neuroscience research to study synaptic physiology, neurotransmitter transport, and neural circuit organization.
SLC17A6 is encoded by the SLC17A6 gene located on human chromosome 11p14. The protein is approximately 582 amino acids long and belongs to the solute carrier 17 family of sodium-dependent phosphate transporters. SLC17A6 localizes to presynaptic vesicles in excitatory neurons, where it uses a proton electrochemical gradient to drive the uptake of glutamate into vesicles prior to release. Its activity directly influences synaptic strength and excitatory signaling fidelity.
The SLC17A6 antibody detects a 60 kilodalton band by western blot and reveals punctate presynaptic staining in neurons and neuropil under immunofluorescence. SLC17A6 expression is region-specific, being highly enriched in subcortical brain regions such as the thalamus, brainstem, and hypothalamus. This distribution distinguishes it from the related vesicular glutamate transporters SLC17A7 (VGLUT1) and SLC17A8 (VGLUT3), which have complementary roles in different neuronal populations.
Functionally, SLC17A6 controls the rate of glutamate release and synaptic efficacy. Knockout studies demonstrate that loss of SLC17A6 leads to severe impairment in excitatory neurotransmission, altered locomotor behavior, and perinatal lethality. Conversely, increased expression of SLC17A6 enhances glutamatergic tone, contributing to excitotoxicity in neurodegenerative disorders such as Parkinson's and Alzheimer's disease.
Beyond its neuronal function, SLC17A6 is expressed in certain endocrine tissues, where it contributes to glutamate-dependent signaling. Because of its precise localization and critical role in neurotransmitter loading, SLC17A6 serves as a robust marker for excitatory synapses. NSJ Bioreagents provides a validated SLC17A6 antibody optimized for western blot, immunohistochemistry, and confocal microscopy, enabling detailed analysis of glutamate transport, synaptic vesicle biology, and excitatory circuitry.
Optimal dilution of the SLC17A6 antibody should be determined by the researcher.
E.coli-derived human VGLUT2/SLC17A6 recombinant protein (Position: M1-K561) was used as the immunogen for the SLC17A6 antibody.
After reconstitution, the SLC17A6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz