- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SIRT6 Antibody / Sirtuin 6 (FY13069)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13069 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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SIRT6 antibody detects Sirtuin 6, a nuclear NAD+-dependent deacetylase that regulates genomic stability, metabolism, and lifespan. The UniProt recommended name is NAD-dependent protein deacylase sirtuin 6 (SIRT6). This enzyme belongs to the sirtuin family of class III histone deacetylases, which use NAD+ as a cofactor to remove acyl groups from lysine residues on histone and non-histone proteins.
Functionally, SIRT6 antibody recognizes a chromatin-associated protein that deacetylates histone H3 at lysine 9 and lysine 56, maintaining telomere integrity and DNA repair efficiency. SIRT6 also promotes base excision repair and regulates transcription by modulating chromatin compaction. It interacts with PARP1 and SNF2H to coordinate double-strand break repair and suppress genomic instability. Beyond chromatin regulation, SIRT6 controls glucose and lipid metabolism by repressing glycolytic gene expression and enhancing mitochondrial respiration.
The SIRT6 gene, located on chromosome 19p13.3, encodes a 355-amino-acid enzyme localized predominantly in the nucleus. SIRT6 expression is enriched in metabolically active tissues such as heart, liver, and brain. It modulates aging-related pathways by influencing insulin sensitivity, inflammation, and DNA repair. Deficiency of SIRT6 in mice causes premature aging, metabolic dysregulation, and shortened lifespan.
Pathologically, dysregulated SIRT6 activity has been implicated in cancer, diabetes, cardiovascular disease, and neurodegeneration. In cancer, SIRT6 may act as a tumor suppressor by limiting glycolysis and maintaining genomic integrity. In metabolic disorders, altered SIRT6 function disrupts energy homeostasis and inflammatory signaling. Research using SIRT6 antibody supports studies of chromatin remodeling, aging, and metabolic control.
SIRT6 antibody is validated for use in western blotting, immunofluorescence, and chromatin immunoprecipitation. It is widely applied in DNA repair and transcriptional regulation studies. NSJ Bioreagents supplies SIRT6 antibody reagents optimized for accurate detection of nuclear sirtuin activity and longevity-related mechanisms.
Structurally, SIRT6 contains a conserved Rossmann-fold domain responsible for NAD+ binding and a zinc-binding module stabilizing its catalytic core. The enzyme exhibits both deacetylase and long-chain deacylase activity, extending its regulatory range to lipid-modified substrates. This antibody aids in investigating SIRT6s central role in chromatin biology and metabolic regulation.
Optimal dilution of the SIRT6 antibody should be determined by the researcher.
E.coli-derived human SIRT6 recombinant protein (Position: D14-S355) was used as the immunogen for the SIRT6 antibody.
After reconstitution, the SIRT6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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