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Home >> Antibodies >> SIRT6 Antibody

SIRT6 Antibody [clone 6C9-D10-D3] (F54008)

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  Catalog No Formulation Size Price (USD)  
Image F54008-0.1ML In PBS with 50% glycerol and 0.03% ProClin 300 0.1 ml 399
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Western blot testing of human Jurkat, MCF7, HCT116, K562, monkey COS7, mouse C2C12, mouse NIH3T3 and human HeLa cell lysates using SIRT6 antibody at 1:500. Predicted molecular weight ~42 kDa.
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Western blot testing of human Jurkat, MCF7, HCT116, K562, monkey COS7, mouse C2C12, mouse NIH3T3 and human HeLa cell lysates using SIRT6 antibody at 1:500. Predicted molecular weight ~42 kDa.
ICC/IF testing of HeLa cells, fixed by 4% paraformaldehyde, with SIRT6 antibody at 1:100.
Immunoprecipitation of SIRT6 from HeLa cell lysate using SIRT6 antibody. The precipitate was subsequently immunoblotted with the same mAb.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat, Primate
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1
Clone Name 6C9-D10-D3
Purity Protein G affinity
UniProt Q8N6T7
Applications Western blot : 1:500
ICC/IF : 1:100
Immunoprecipitation : suitable
Limitations This SIRT6 antibody is available for research use only.
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Description

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. [UniProt]

Application Notes

The stated application concentrations are suggested starting points. Titration of the SIRT6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A human recombinant protein was used as the immunogen for this SIRT6 antibody.

Storage

Store the SIRT6 antibody at -20oC.

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