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Home >> Antibodies >> SHP-1 Antibody / PTPN6 / PTP1C

SHP-1 Antibody / PTPN6 / PTP1C [clone PTPN6/7544] (V4252)

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  Catalog No Formulation Size Price (USD)  
Image V4252-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V4252-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V4252SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC staining of FFPE human tonsil tissue with SHP-1 antibody (clone PTPN6/7544). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human tonsil tissue with SHP-1 antibody (clone PTPN6/7544). Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free SHP-1 antibody (clone PTPN6/7544) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG1, kappa
Clone Name PTPN6/7544
Purity Protein A/G affinity
UniProt P29350
Localization Cytoplasm, Nucleus
Applications Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT
Limitations This SHP-1 antibody is available for research use only.
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Description

PTPN6, which is also designated as SHP-1 and PTP1C, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies suggest that it may be helpful in differentiating mantle/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative).

Application Notes

Optimal dilution of the SHP-1 antibody should be determined by the researcher.

Immunogen

A recombinant partial protein sequence (within amino acids 395-595) from the human protein was used as the immunogen for the SHP-1 antibody.

Storage

Aliquot the SHP-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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