- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SHP-1 Antibody / PTPN6 (F54777)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F54777-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 399 | |
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F54777-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 185 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Purified |
| UniProt | P29350 |
| Localization | Cytoplasmic, nuclear |
| Applications | Immunofluorescence : 1:25 Immunohistochemistry (FFPE) : 1:25 Western blot : 1:500-1:2000 |
| Limitations | This SHP-1 antibody is available for research use only. |
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PTPN6 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.
The stated application concentrations are suggested starting points. Titration of the SHP-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 247-277 from the human protein was used as the immunogen for the SHP-1 antibody.
Aliquot the SHP-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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