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SH2 domain-containing protein 4A, also called Protein phosphatase 1 regulatory subunit 38 (PPP1R38) is a protein that in humans is encoded by the SH2D4A gene. Using exon trapping and exon linking at chromosome 8p22 cloned SH2D4A, which they called SH2A. The deduced 454-amino acid protein contains a single SH2 domain. RT-PCR and Northern blot analysis detected ubiquitous expression of 3 SH2A transcripts, as well as aberrant expression in some cancer cell lines. Dai et al. (2002) concluded that SH2A is a docking protein that may be involved in signal transduction.
Optimal dilution of the SH2D4A antibody should be determined by the researcher.
E. coli-derived recombinant human protein (amino acids R42-E454) was used as the immunogen for the SH2D4A antibody.
After reconstitution, the SH2D4A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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