- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SGCE Antibody / Epsilon-sarcoglycan (RQ7584)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ7584 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | O43556 |
| Localization | Cytoplasmic |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This SGCE antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
SGCE antibody detects Epsilon-sarcoglycan, a transmembrane glycoprotein encoded by the SGCE gene that is part of the dystrophin-associated glycoprotein complex (DGC) responsible for maintaining muscle cell membrane stability. The UniProt recommended name is Epsilon-sarcoglycan (SGCE). This protein belongs to the sarcoglycan family, which also includes alpha, beta, gamma, and delta isoforms, all of which assemble into a multimeric complex linking the cytoskeleton to the extracellular matrix.
Epsilon-sarcoglycan functions as a single-pass membrane protein primarily expressed in skeletal and cardiac muscle, where it associates with dystrophin, dystroglycans, and other sarcoglycans to preserve muscle integrity during contraction. Loss or mutation of SGCE disrupts the dystrophin complex and can lead to membrane fragility and progressive muscular degeneration. In addition to its structural role, Epsilon-sarcoglycan contributes to cellular signaling by facilitating communication between the cytoskeleton and the extracellular environment.
Functionally, SGCE antibody recognizes a protein that contains an extracellular domain with multiple glycosylation sites, a hydrophobic transmembrane segment, and a short cytoplasmic tail. This structure enables Epsilon-sarcoglycan to stabilize cell membranes and coordinate intracellular signaling responses. In neurons, the protein is also expressed in specific brain regions involved in motor control, suggesting a role beyond muscle physiology.
Mutations in SGCE are linked to myoclonus-dystonia syndrome (MDS), a dominantly inherited movement disorder characterized by myoclonic jerks and dystonia. The disorder arises from loss of function of the paternal SGCE allele, as the maternal copy is typically silenced by genomic imprinting. Immunohistochemical analysis using Epsilon-sarcoglycan antibody has demonstrated reduced or absent protein expression in affected individuals, making it a useful marker in research focused on dystonia and related neuromuscular disorders.
SGCE antibody is validated for use in western blotting, immunohistochemistry, and immunofluorescence applications to study dystrophin-associated protein complexes, muscle cell membrane biology, and neuronal signaling. NSJ Bioreagents provides SGCE antibody reagents optimized for research on sarcoglycan structure, dystonia pathogenesis, and membrane-cytoskeleton interactions.
Structurally, Epsilon-sarcoglycan forms part of a larger dystrophin complex that bridges the actin cytoskeleton to extracellular laminin, ensuring proper mechanical support and signal transduction in muscle cells. Research using SGCE antibody continues to advance understanding of how defects in sarcoglycan family proteins contribute to muscular and neurological disease.
Optimal dilution of the SGCE antibody should be determined by the researcher.
E. coli-derived recombinant human protein (amino acids Y38-D407) was used as the immunogen for the SGCE antibody.
After reconstitution, the SGCE antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
