- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Serum Amyloid P Component Antibody / PTX2 Antibody recognizes serum amyloid P component (SAP), a secreted glycoprotein encoded by the APCS gene and also known as PTX2. SAP belongs to the pentraxin family of calcium-dependent ligand-binding proteins and circulates as a stable oligomer composed of identical subunits. It participates in interactions with extracellular proteins, chromatin components and cellular material generated during tissue damage.
Serum amyloid P component is closely associated with pathological amyloid deposits. SAP binds proteins arranged in the characteristic amyloid cross-beta structure and is found in essentially all types of amyloid deposits. Its resistance to proteolysis and ability to stabilize amyloid fibrils have made it an important target in studies of amyloid persistence, clearance and disease mechanisms. Despite the similarity in terminology, serum amyloid P component is distinct from the serum amyloid A family of proteins.
PTX2 also has functions extending beyond amyloid biology. The protein can bind DNA, histones and chromatin and has been implicated in the handling of nuclear material released from damaged cells. SAP can recognize apoptotic cells and may participate in their clearance, connecting pentraxin biology with innate immune homeostasis. These properties make PTX2 Antibody research relevant to studies of extracellular protein deposition, cellular damage and inflammatory processes.
The APCS protein is synthesized primarily by the liver and secreted into the circulation. Individual subunits have a molecular weight of approximately 25 kDa and assemble into the characteristic pentraxin structure. Calcium-dependent interactions contribute to SAP binding to amyloid fibrils and several other biological ligands.
NSJ Bioreagents offers this rabbit polyclonal antibody for research into serum amyloid P component expression and PTX2 biology. For our primary APCS resource and a Protein Microarray Validated monoclonal reagent, see our Serum Amyloid P Antibody APCS/3240 / APCS Antibody page. A Serum Amyloid P Component Antibody provides a research tool for investigating PTX2, pentraxin function and amyloid-associated processes.
Titration of the Serum Amyloid P Component Antibody / PTX2 Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A recombinant human protein corresponding to amino acids H20-L220 was used as the immunogen for the Serum Amyloid P Component Antibody.
The lyophilized Serum Amyloid P Component Antibody can be stored at 4oC to -20oC. After reconstitution, aliquot and store at -20oC. Avoid repeated freeze/thaws.
PTX2 antibody, APCS antibody, Serum amyloid P component antibody, SAP antibody, Pentraxin 2 antibody, Amyloid P component antibody
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