- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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SERPINB5 antibody, also known as Maspin antibody, recognizes a non-inhibitory member of the serpin superfamily encoded by the SERPINB5 gene on chromosome 18q21.33. SERPINB5, commonly referred to as Maspin, is primarily localized to the cytoplasm and nucleus of epithelial cells. Unlike many serpins, Maspin does not function as a classical protease inhibitor but instead regulates cell adhesion, migration, apoptosis, and differentiation. It is widely expressed in normal epithelial tissues including breast, prostate, lung, and skin, where it contributes to epithelial homeostasis.
SERPINB5 has been characterized as a tumor suppressor protein due to its role in inhibiting tumor invasion and metastasis. Maspin modulates cell-matrix interactions, influences integrin signaling pathways, and affects extracellular matrix remodeling. SERPINB5 antibody is commonly used in cancer research to evaluate epithelial differentiation and to study changes in Maspin expression during tumor progression. Altered localization, such as nuclear versus cytoplasmic distribution, has been associated with differences in tumor behavior and clinical outcome.
Structurally, Maspin belongs to the ovalbumin clade of serpins but lacks key residues required for classical protease inhibitory activity. Instead, it interacts with components of the extracellular matrix and intracellular signaling pathways to influence cell motility and apoptosis. SERPINB5 expression is often reduced or lost in aggressive carcinomas, while preserved or increased expression may correlate with less invasive phenotypes in certain tumor types.
In addition to oncology applications, Maspin participates in epithelial differentiation and tissue remodeling processes. Its dual cytoplasmic and nuclear localization makes it useful for studying subcellular distribution patterns in epithelial biology. Clone SERPINB5/4974 recognizes SERPINB5 and is suitable for detecting Maspin expression in relevant research applications.
Optimal dilution of the SERPINB5 antibody should be determined by the researcher.
A recombinant fragment of human SERPINB5 protein (within amino acids 1-200) was used as the immunogen for the SERPINB5 antibody.
Aliquot the SERPINB5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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