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Home >> Antibodies >> Serotonin Transporter Antibody / SERT / SLC6A4

Serotonin Transporter Antibody / SERT / SLC6A4 (R30795)

  Catalog No Formulation Size Price (USD)  
Image R30795 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of Serotonin transporter antibody and rat brain tissue lysate. Expected molecular weight: ~70/85-95kDa (unmodified/glycosylated).
IHC-P: Serotonin transporter antibody testing of rat brain tissue
Availability 1-3 business days
Species Reactivity Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
UniProt P31652
Localization Cell membrane
Applications Western blot : 0.5-1ug/ml
IHC (FFPE) : 0.5-1ug/ml
Limitations This Serotonin transporter antibody is available for research use only.
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Description

SLC6A4 (Solute carrier family 6, member 4), also known as SERT (Serotonin transporter), is a monoamine transporter protein. The SLC6A4 gene spans 31 kb and contains 14 exons. This protein integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is the target of many antidepressant medications, including those of the SSRI class. It is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.

Application Notes

The stated application concentrations are suggested starting amounts. Titration of the Serotonin transporter antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

An amino acid sequence from the N-terminus of rat Serotonin transporter (NSQKVLSECKDREDCQEN) was used as the immunogen for this Serotonin transporter antibody.

Storage

After reconstitution, the Serotonin transporter antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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