SERBP1 Antibody / mRNA Binding Protein Antibody [clone SERBP1/3491] (V7558)

Description

SERPINE1 mRNA binding protein 1 (SERBP1) is an RNA-associated regulatory protein involved in mRNA stability, translational regulation, stress-response signaling, and post-transcriptional control of gene expression. SERBP1 functions through interactions with specific mRNA transcripts and ribonucleoprotein-associated regulatory complexes that influence transcript turnover, protein translation, and cellular adaptation pathways. SERBP1 Antibody is useful for investigations involving RNA metabolism, stress-response signaling, translational control, and post-transcriptional regulatory biology.

SERBP1 antibody, also referred to as SERPINE1 mRNA binding protein 1 antibody, PAI-RBP1 antibody, and Plasminogen activator inhibitor 1 RNA-binding protein antibody in the literature, recognizes a predominantly cytoplasmic RNA-binding protein encoded on chromosome 1p31.1. SERBP1 localizes mainly within cytoplasmic ribonucleoprotein-associated compartments where it contributes to mRNA stabilization, translational regulation, and stress granule-associated signaling pathways. Expression of SERBP1 has been associated with cellular stress adaptation, tumor-associated signaling, hypoxia-responsive pathways, and regulation of mRNA networks involved in proliferation and survival signaling.

SERBP1 Antibody / mRNA Binding Protein Antibody (clone SERBP1/3491) is uniquely positioned for studies involving RNA regulatory signaling and post-transcriptional cellular control pathways. This mouse monoclonal antibody demonstrates strong western blot and immunohistochemical detection together with highly selective HuProt(TM) microarray specificity validation against more than 19,000 full-length human proteins. The combined validation profile supports use of clone SERBP1/3491 in investigations involving translational regulation, RNA metabolism-associated signaling, and stress-response-associated cellular regulation.

Analysis of HuProt(TM) microarrays containing more than 19,000 individually purified full-length human proteins demonstrated highly selective recognition of SERBP1 by clone SERBP1/3491. In HuProt(TM) analysis, the Z-score represents the strength of antibody binding signal relative to the overall array mean, while the S-score reflects target specificity relative to the next highest ranked protein signal. Elevated S-score separation supports preferential target recognition and reduced off-target binding across the tested human proteome. This specificity validation strategy supports highly selective detection of RNA-associated regulatory proteins in complex tissue systems.

SERBP1 contributes directly to post-transcriptional regulation through interactions with mRNA transcripts associated with stress adaptation, hypoxia signaling, cellular proliferation, and translational control pathways. Dysregulated SERBP1-associated signaling has been linked to tumor progression, altered stress-response pathways, and cancer-associated translational reprogramming. Because SERBP1 functions at the interface of RNA metabolism and cellular adaptation signaling, it serves as an important marker for investigations involving RNA regulatory networks and stress-associated cellular biology.

This SERBP1 Antibody supports research involving mRNA regulation, translational control, RNA metabolism-associated signaling, stress-response pathways, hypoxia-associated signaling, ribonucleoprotein biology, and post-transcriptional cellular regulation. Clone SERBP1/3491 may be incorporated into western blot, immunohistochemistry, and tissue-based investigations examining RNA regulatory pathway organization in normal and diseased tissues.

Explore additional RNA regulatory and stress-response signaling markers on our Signal Transduction Antibodies landing page, including antibodies targeting translational control, post-transcriptional regulation, and cellular adaptation-associated pathways.

Application Notes

Optimal dilution of the SERBP1 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Immunogen

A recombinant human partial protein corresponding to amino acids 3-139 was used as the immunogen for the SERBP1 antibody.

Storage

Store the SERBP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Alternate Names

SERBP1 antibody, SERPINE1 mRNA binding protein 1 antibody, PAI-RBP1 antibody, Plasminogen activator inhibitor 1 RNA-binding protein antibody, mRNA binding protein antibody, RNA regulatory protein antibody