- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SELT Antibody / SELENOT (RQ7575)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ7575 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P62341 |
| Localization | Cytoplasm (ER) |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Flow Cytometry : 1-3ug/million cells Immunofluorescence : 5ug/ml Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This SELT antibody is available for research use only. |
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SELT antibody targets Selenoprotein T, also known as SELENOT, a small endoplasmic reticulum-resident selenoprotein that plays an important role in cellular redox regulation and secretory pathway homeostasis. Selenoprotein T is localized primarily to the endoplasmic reticulum membrane, where it contains a conserved redox-active motif typical of thioredoxin-like selenoproteins. The SELT gene encodes a protein that belongs to the selenoprotein family, characterized by the incorporation of the amino acid selenocysteine, which confers enhanced redox activity compared to cysteine-containing proteins. This biochemical property underlies the protein's involvement in maintaining redox balance during protein folding and secretion.
SELT antibody is widely used in research settings to study Selenoprotein T expression and distribution in secretory cells and metabolically active tissues. Selenoprotein T is highly expressed in endocrine and neuroendocrine systems, including pancreatic islets, adrenal tissue, and neuronal populations, where regulated secretion and oxidative control are tightly linked. Its expression pattern suggests a specialized role in cells with high secretory demand, where oxidative stress can arise as a consequence of intense protein synthesis and hormone production.
Functionally, Selenoprotein T contributes to intracellular redox signaling and protection against oxidative stress, supporting cell survival and proper secretory function. Studies have shown that SELENOT activity is particularly important during development and cellular differentiation, especially in tissues undergoing rapid growth or hormonal maturation. Loss or reduction of Selenoprotein T expression has been associated with impaired secretory capacity and increased sensitivity to oxidative damage, highlighting its protective role within the endoplasmic reticulum environment.
SELT antibody is also relevant for investigating disease-associated processes. Altered SELENOT expression or function has been linked to metabolic disorders, endocrine dysfunction, and stress-related cellular responses. In pancreatic beta cells, Selenoprotein T is implicated in insulin biosynthesis and secretion, making it of interest in diabetes-related research. In the nervous system, its role in redox homeostasis supports neuronal viability under oxidative or inflammatory stress, connecting SELENOT to neurodegenerative and neuroinflammatory conditions.
At the molecular level, Selenoprotein T is encoded by a gene located on human chromosome 3 and produces a relatively small protein that integrates into the endoplasmic reticulum membrane. It interacts with components of the secretory machinery and redox regulators, contributing to proper protein maturation and cellular signaling. SELT antibody enables researchers to examine these interactions and to map expression changes across tissues, developmental stages, and experimental models.
Overall, SELT antibody is a valuable tool for studying redox biology, endocrine and neuroendocrine regulation, and cellular stress responses. By enabling detection of Selenoprotein T in research applications, this antibody supports investigations into fundamental cell biology as well as disease mechanisms related to oxidative imbalance and secretory dysfunction.
Optimal dilution of the SELT antibody should be determined by the researcher.
E. coli-derived recombinant human protein (amino acids S20-S195) was used as the immunogen for the SELT antibody.
After reconstitution, the SELT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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