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Home >> Antibodies >> SDHB Antibody

SDHB Antibody [clone SDHB/2382] (V8073)

  Catalog No Formulation Size Price (USD)  
Image V8073-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V8073-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V8073SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated
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Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using SDHB antibody (clone SDHB/2382). These results demonstrate the foremost specificity of the SDHB/2382 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
SDS-PAGE analysis of purified, BSA-free SDHB antibody (clone SDHB/2382) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, kappa
Clone Name SDHB/2382
Purity Protein G affinity chromatography
UniProt P21912
Applications Western blot : 0.5-1ug/ml
Limitations This SDHB antibody is available for research use only.
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Description

Succinate dehydrogenase (SDH) is Complex II in the mitochondria, vital for mitochondrial electron transport, as well as Krebs cycle function.Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB) and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. The SDH complex functions as a tumor suppressor. Loss of any subunit proteins lead to destabilization of the complex and tumor formation.Antibody to SDHB is helpful in the identification of phaeochromocytomas, paragangliomas and GIST.

Application Notes

Optimal dilution of the SDHB antibody should be determined by the researcher.

Immunogen

A recombinant human partial protein (amino acids 165-273) were used as the immunogen for this SDHB antibody.

Storage

Store the SDHB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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