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Home >> Antibodies >> SDHA Antibody

SDHA Antibody (R32062)

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Image R32062 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 419
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Western blot testing of 1) rat liver, 2) mouse liver, 3) rat brain, 4) mouse brain, 5) SMMC, 6) human placenta, and 7) SW620 lysate with SDHA antibody. Expected/observed molecular weight ~73 kDa.
Western blot testing of 1) rat liver, 2) mouse liver, 3) rat brain, 4) mouse brain, 5) SMMC, 6) human placenta, and 7) SW620 lysate with SDHA antibody. Expected/observed molecular weight ~73 kDa.
Availability 1-3 business days
Species Reactivity Human, Mouse, Rat
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt P31040
Applications Western blot : 0.1-0.5ug/ml
Limitations This SDHA antibody is available for research use only.
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Description

Complex II of the mitochondrial respiratory chain, also known as succinate dehydrogenase or succinate:ubiquinone oxidoreductase, consists of 4 nuclear-encoded polypeptides, these are the flavoprotein subunit (SDHA), the iron sulfur protein subunit (SDHB), and the integral membrane protein subunits SDHC and SDHD. SDHA is an acronym for succinate dehydrogenase complex subunit A. The succinate dehydrogenase (SDH) protein complex catalyzes the oxidation of succinate (succinate + ubiquinone => fumarate + ubiquinol). The SDHA subunit is connected to the SDHB subunit on the hydrophilic, catalytic end of the complex, and weighs 72.7 kDA. Mutations in the SDHA subunit have a distinct pathology from mutations in the SDHB/SDHC/SDHD subunits; it is the only subunit to never have shown tumor suppressor behaviour. Heterozygous carriers of an SDHA mutation do not develop paragangliomas as has been seen for mutations in the other subunits. This appears to be due to the expression of two similar SDHA genes (Types I and II) in the paraganglia system.

Application Notes

Optimal dilution of the SDHA antibody should be determined by the researcher.

Immunogen

Amino acids 44-380 of human SDHA were used as the immunogen for the SDHA antibody.

Storage

After reconstitution, the SDHA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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