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- Tel: 858.663.9055
- Email: info@nsjbio.com
Putative Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. SCML1 (sex comb on midleg-like 1 (Drosophila)), is a 329 amino acid PcG protein belonging to the SCM family. Localizing to nucleus, SCML1 plays a role in testis development, spermatogenesis and embryonal development. While ubiquitously expressed, SCML1 is found at highest levels in adult skeletal muscle, heart and fetal liver. SCML1 contains one SAM (sterile alpha motif) domain and is encoded by a gene that spans 18 kb, contains 6 exons, maps to human chromosome Xp22.13, and is transcribed from telomere to centromere. Three SCML1 isoforms exist as a result of alternative splicing events.
Optimal dilution of the SCML1 antibody should be determined by the researcher.
E. coli-derived recombinant human protein (amino acids E8-K322) was used as the immunogen for the SCML1 antibody.
After reconstitution, the SCML1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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