- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SATB2 Antibody for WB [clone SATB2/8877R] (V4935)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4935-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4935-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
|
V4935SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | SATB2/8877R |
| Purity | Protein A/G affinity |
| UniProt | Q9UPW6 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT Western Blot : 2-4ug/ml |
| Limitations | This SATB2 antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
SATB2 Antibody for WB (clone SATB2/8877R) recognizes Special AT-rich sequence-binding protein 2, a nuclear chromatin organizer encoded by the SATB2 gene on chromosome 2q33.1. SATB2 is a DNA-binding transcriptional regulator that coordinates higher-order chromatin architecture with gene expression. The protein contains two CUT domains and a homeodomain that enable sequence-specific DNA interaction and recruitment of regulatory complexes. SATB2 localizes predominantly to the nucleus, where it functions as a genome organizer linking matrix attachment regions to transcriptional control mechanisms.
SATB2 plays a central role in embryonic development, particularly in cortical neuron specification, craniofacial patterning, and osteoblast differentiation. In the developing cerebral cortex, SATB2 regulates projection neuron identity and gene expression programs required for proper cortical connectivity. In skeletal tissues, it supports osteogenic lineage commitment and bone formation. In adult tissues, SATB2 expression is most prominent in glandular epithelial cells of the lower gastrointestinal tract, especially colorectal mucosa, where it contributes to epithelial differentiation and maintenance of regional identity.
Alterations in SATB2 expression or function have been associated with developmental disorders and are widely investigated in colorectal cancer research. SATB2 is frequently studied as a marker of colorectal epithelial origin due to its consistent expression in normal and malignant colorectal epithelium. In experimental settings, analysis of SATB2 protein levels can provide insight into differentiation status, lineage specification, and transcriptional regulation pathways in epithelial and neuronal systems.
As a rabbit monoclonal antibody optimized for western blot applications, clone SATB2/8877R is designed to detect SATB2 protein in denatured samples following SDS-PAGE separation and membrane transfer. Monoclonal epitope specificity supports consistent band detection and reduced non-specific background. SATB2 Antibody for WB (SATB2/8877R) is suitable for investigating SATB2 protein expression in research studies focused on colorectal biology, neuronal development, skeletal differentiation, and chromatin organization mechanisms.
Optimal dilution of the SATB2 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 200-300) from the human protein was used as the immunogen for the SATB2 antibody for WB.
Aliquot the SATB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
