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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SATB2 Antibody Recombinant Rabbit MAb [clone SATB2/8292R] (V4934)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4934-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4934-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4934SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | SATB2/8292R |
| Purity | Protein A/G affinity |
| UniProt | Q9UPW6 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This SATB2 antibody is available for research use only. |
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SATB2 Antibody Recombinant Rabbit MAb (clone SATB2/8292R) recognizes Special AT-rich sequence-binding protein 2, a nuclear chromatin organizer encoded by the SATB2 gene on chromosome 2q33.1. SATB2 functions as a genome architectural protein that binds AT-rich DNA sequences and anchors chromatin to the nuclear matrix, thereby coordinating higher-order chromatin looping with transcriptional regulation. The protein contains two CUT domains and a homeodomain that mediate sequence-specific DNA binding and recruitment of transcriptional regulatory complexes. SATB2 is predominantly localized to the nucleus, where it exhibits a granular or reticular staining pattern consistent with its role in chromatin remodeling and spatial genome organization.
SATB2 plays a critical role in embryonic development, particularly in cortical neuron differentiation, craniofacial morphogenesis, and osteoblast lineage commitment. In the developing cerebral cortex, SATB2 regulates projection neuron identity and gene expression programs required for appropriate neuronal connectivity. In skeletal tissues, it supports osteogenic differentiation by modulating transcriptional networks involved in bone formation. In adult tissues, SATB2 expression is most prominent in epithelial cells of the lower gastrointestinal tract, especially colorectal mucosa, where it contributes to maintenance of regional epithelial identity and differentiation.
Alterations in SATB2 expression or function have been associated with developmental syndromes and are widely investigated in colorectal cancer research. SATB2 is frequently studied as a nuclear marker of colorectal epithelial origin due to its consistent expression in normal and malignant colorectal epithelium. Evaluation of SATB2 protein expression can provide insight into lineage specification, differentiation status, and transcriptional regulatory pathways in epithelial, neuronal, and skeletal systems.
As a recombinant rabbit monoclonal antibody, clone SATB2/8292R is engineered for epitope-specific recognition of the SATB2 protein with defined binding characteristics and improved lot-to-lot consistency. Recombinant monoclonal design supports reproducible nuclear detection and reduced non-specific background. SATB2 Antibody recombinant rabbit mAb SATB2/8292R is suitable for detecting nuclear SATB2 expression in research applications focused on colorectal biology, neuronal development, skeletal differentiation, and chromatin organization mechanisms.
Optimal dilution of the SATB2 antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 150-350) from the human protein was used as the immunogen for the SATB2 antibody recombinant rabbit mAb SATB2/8292R.
Aliquot the SATB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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