- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
SATB2 Antibody Recombinant Mouse MAb [clone rSATB2/6929] (V9501)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9501-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V9501-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9501SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rSATB2/6929 |
| Purity | Protein A/G affinity |
| UniProt | Q9UPW6 |
| Localization | Nuclear |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This SATB2 antibody is available for research use only. |
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SATB2 Antibody Recombinant Mouse MAb clone rSATB2/6929 recognizes Special AT-rich sequence-binding protein 2, a nuclear chromatin organizer encoded by the SATB2 gene located on chromosome 2q33.1. SATB2 functions as a DNA-binding transcriptional regulator that anchors specialized AT-rich genomic regions to the nuclear matrix, coordinating higher-order chromatin looping with gene expression control. The protein contains two CUT domains and a homeodomain that mediate sequence-specific DNA binding and recruitment of transcriptional regulatory complexes. SATB2 localizes predominantly to the nucleus, where it typically displays a granular or reticular staining pattern reflecting its role in chromatin remodeling and spatial genome organization.
SATB2 is critically involved in embryonic development, particularly in corticogenesis, craniofacial morphogenesis, and osteoblast differentiation. In the developing cerebral cortex, SATB2 regulates projection neuron identity and gene expression programs required for proper cortical connectivity. In skeletal tissues, it contributes to osteogenic lineage commitment and bone formation by modulating transcriptional networks associated with differentiation. In adult tissues, SATB2 expression is most prominent in glandular epithelial cells of the lower gastrointestinal tract, especially colorectal mucosa, where it supports maintenance of regional epithelial identity.
Altered SATB2 expression has been investigated in developmental disorders and colorectal cancer research. SATB2 is widely studied as a nuclear marker of colorectal epithelial origin due to its consistent expression in normal and malignant colorectal epithelium. Evaluation of SATB2 protein expression in experimental models can provide insight into differentiation status, lineage specification, and transcriptional regulatory mechanisms in epithelial, neuronal, and skeletal systems.
As a recombinant mouse monoclonal antibody, clone rSATB2/6929 is engineered for epitope-specific recognition of the SATB2 protein, supporting reproducible and consistent performance. Recombinant monoclonal design enhances lot-to-lot consistency and defined binding characteristics. SATB2 Antibody recombinant mouse mAb rSATB2/6929 is suitable for detecting nuclear SATB2 expression in research studies focused on colorectal biology, neuronal development, skeletal differentiation, and chromatin organization.
Optimal dilution of the SATB2 antibody should be determined by the researcher.
A portion of amino acids 200-300 was used as the immunogen for the SATB2 antibody recombinant mouse mAb rSATB2/6929.
Aliquot the SATB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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