- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
S100G Antibody / Calcium Transport and Absorption Marker Antibody [clone S100G/7462] (V5343)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5343-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V5343-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5343SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2, kappa |
| Clone Name | S100G/7462 |
| Purity | Protein A/G affinity |
| UniProt | P29377 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This S100G Antibody / Calcium Transport and Absorption Marker Antibody is available for research use only. |
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S100 calcium binding protein G (S100G) is a small cytoplasmic calcium-binding protein encoded by the S100G gene and widely known as Calbindin D9K, a specialized regulator of transcellular calcium transport in epithelial tissues. The S100G Antibody is used to study this protein, which is highly enriched in absorptive epithelia such as the small intestine, renal distal tubules, and placenta, where tightly controlled calcium flux is required for systemic mineral balance and skeletal integrity. S100G belongs to the S100 family of EF-hand calcium-binding proteins but is functionally distinct due to its dedicated role in calcium buffering and transport rather than inflammatory or cytoskeletal signaling.
S100G antibody, also known as Calbindin D9K antibody or calcium binding protein intestinal antibody, recognizes a protein that operates as a high-affinity intracellular calcium carrier. Upon calcium entry through apical channels such as TRPV6 in enterocytes, S100G binds calcium ions and facilitates their diffusion across the cytoplasm toward basolateral export systems including plasma membrane Ca2+-ATPases and sodium-calcium exchangers. This process supports efficient dietary calcium absorption and prevents cytotoxic accumulation of free intracellular calcium, making S100G essential for epithelial calcium handling under both basal and stimulated conditions.
Expression of S100G is strongly induced by active vitamin D signaling through the vitamin D receptor, positioning it as a key downstream effector of endocrine regulation of calcium metabolism. In intestinal tissues, S100G expression correlates with enhanced calcium uptake, while in kidney tissues it contributes to calcium reabsorption in distal nephron segments. This hormone-responsive expression pattern makes S100G a valuable marker for studying vitamin D-dependent pathways, nutrient absorption, and mineral homeostasis in both physiological and disease contexts.
Clone S100G/7462 antibody is designed to detect S100G expression in research applications focused on epithelial function and calcium transport biology. The restricted tissue distribution of S100G enhances its utility as a marker for absorptive epithelial cell populations, particularly in gastrointestinal and renal systems. Its consistent cytoplasmic localization provides clear detection of calcium-transporting cells, supporting studies of epithelial differentiation, functional zonation, and hormone-responsive gene expression.
Structurally, S100G contains two EF-hand calcium-binding motifs that enable reversible calcium binding without triggering downstream signaling cascades. Unlike other S100 proteins that interact with cytoskeletal or transcriptional targets, S100G primarily functions as a mobile calcium buffer, maintaining intracellular calcium gradients during active transport. It may also interact transiently with transport-associated proteins to facilitate directional calcium movement, further reinforcing its role in epithelial calcium handling.
Altered S100G expression has been associated with disorders of calcium absorption, including osteoporosis, vitamin D deficiency, and intestinal malabsorption syndromes. Its role in mineral metabolism also links it to broader physiological processes such as bone remodeling and endocrine regulation. This S100G Antibody supports detailed investigation of calcium transport mechanisms, epithelial physiology, and hormone-regulated pathways central to maintaining systemic calcium balance.
This S100G antibody is part of a broader antibody panel offered by NSJ Bioreagents.
Optimal dilution of the S100G Antibody / Calcium Transport and Absorption Marker Antibody should be determined by the researcher.
Recombinant full-length human S100G protein was used as the immunogen for the S100G antibody.
Aliquot the S100G antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
S100G antibody, Calbindin D9K antibody, Calcium binding protein intestinal antibody, CABP9K antibody, S100 calcium binding protein G antibody
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