- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
RPS19BP1 Antibody / Ribosomal protein S19-binding protein 1 (FY12727)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12727 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
RPS19BP1 antibody detects Ribosomal protein S19-binding protein 1 (also known as RPS19BP1 or CGI-96), a conserved nucleolar protein implicated in ribosome biogenesis, RNA processing, and cell proliferation. Encoded by the RPS19BP1 gene on chromosome 22q13.2, this protein binds ribosomal protein S19 and possibly other ribosomal components, assisting in pre-rRNA maturation and ribosome assembly. RPS19BP1 contains coiled-coil and low-complexity regions that may mediate protein-protein interactions within the nucleolus. Although initially identified as a ribosome-associated factor, emerging evidence suggests roles in DNA repair and RNA metabolism.
RPS19BP1 is predominantly localized to the nucleolus and nucleoplasm, where it contributes to the assembly of ribosomal subunits and maintenance of rRNA transcription. Depletion of RPS19BP1 results in reduced 40S ribosomal subunit formation and impaired protein synthesis. Given the central role of ribosome biogenesis in cell growth, dysregulation of RPS19BP1 affects proliferation and stress response pathways. The protein has been linked to hematopoietic development, as mutations or altered expression may influence erythropoiesis through its association with RPS19, a protein mutated in Diamond-Blackfan anemia.
The RPS19BP1 antibody is used in molecular biology and hematology research to study nucleolar function, ribosomal assembly, and cell growth control. Western blot analysis identifies a 58 kilodalton band corresponding to RPS19BP1, while immunofluorescence demonstrates strong nucleolar staining patterns. In proliferating cells, RPS19BP1 colocalizes with fibrillarin and other rRNA processing factors. Because nucleolar integrity is sensitive to stress, this antibody is also applied in experiments assessing nucleolar stress and its effects on p53 stabilization.
Beyond ribosome biogenesis, RPS19BP1 may have additional regulatory roles in chromatin remodeling and transcriptional control. Its interaction network includes several chromatin-binding and RNA-processing proteins. Aberrant expression of RPS19BP1 has been noted in certain cancers, linking ribosomal stress to tumorigenesis. The RPS19BP1 antibody therefore provides an essential tool for investigating nucleolar function, ribosomal disorders, and the interface between protein synthesis and cell cycle control. NSJ Bioreagents offers this antibody validated for western blotting, immunofluorescence, and immunohistochemistry for reliable detection of RPS19BP1 in diverse experimental systems.
Optimal dilution of the RPS19BP1 antibody should be determined by the researcher.
E.coli-derived human RPS19BP1 recombinant protein (Position: M1-S136) was used as the immunogen for the RPS19BP1 antibody.
After reconstitution, the RPS19BP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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