RNA Helicase A Antibody / DHX9 (RQ5970)

Description

RNA Helicase A (DHX9) is an ATP-dependent DExH-box helicase that remodels structured RNA and RNA–DNA hybrids to coordinate transcription, co-transcriptional RNA processing, and nuclear export. Active in both nucleus and cytoplasm, DHX9 resolves R-loops, engages G-quadruplex structures, and modulates ribonucleoprotein assembly, thereby safeguarding genome integrity and ensuring accurate gene expression programs.

Functionally, DHX9 intersects with DNA damage response pathways and innate immune signaling, influencing antiviral defenses and replication stress tolerance. Dysregulated DHX9 expression has been linked to tumor progression and therapeutic response across multiple cancers, where altered RNA metabolism and genome stability contribute to disease phenotypes. Its broad involvement makes DHX9 a key biomarker for studies spanning oncology, virology, and RNA biology.

The RNA Helicase A antibody enables specific detection of endogenous DHX9 in cell and tissue samples, supporting applications such as western blot, immunofluorescence, immunohistochemistry, and immunoprecipitation. Researchers rely on the RNA Helicase A antibody to quantify expression dynamics, map subcellular localization, and probe protein–RNA interactions under physiological or stress conditions. With high specificity and reproducible performance, the RNA Helicase A antibody is a cornerstone reagent for dissecting RNA metabolism, genome maintenance, and host–pathogen interactions.

Application Notes

Optimal dilution of the RNA Helicase A antibody should be determined by the researcher.

Immunogen

Recombinant human protein (amino acids E396-E759) was used as the immunogen for the RNA Helicase A antibody.

Storage

After reconstitution, the RNA Helicase A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.