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Home >> Antibodies >> RICTOR Antibody

RICTOR Antibody (F53372)

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  Catalog No Formulation Size Price (USD)  
Image F53372-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F53372-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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Western blot testing of RICTOR antibody at 1:2000 dilution + HepG2 lysate; Predicted molecular weight ~200 kDa.
Western blot testing of RICTOR antibody at 1:2000 dilution + HepG2 lysate; Predicted molecular weight ~200 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt Q6R327
Applications Western blot : 1:2000
Limitations This RICTOR antibody is available for research use only.
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Description

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.

Application Notes

Titration of the RICTOR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This RICTOR antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1068-1102 amino acids from the Central region of human RICTOR.

Storage

Aliquot the RICTOR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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