- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
RHOBTB2 Antibody / Deleted in breast cancer gene 2 [clone DBC2/12581] (V5894)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V5894-100UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 559 | |
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V5894-20UG | 0.2 mg/ml in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 259 | |
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V5894SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
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| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | DBC2/12581 |
| UniProt | Q9BYZ6 |
| Localization | Cytoplasm, Secreted in plasma |
| Applications | ELISA : |
| Limitations | This RHOBTB2/Deleted in breast cancer gene 2 antibody is available for research use only. |
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RHOBTB2 Antibody recognizes Deleted in breast cancer gene 2, a member of the RhoBTB subfamily of atypical Rho GTPase proteins that is widely referred to as DBC2 in the literature. Deleted in breast cancer gene 2 is predominantly localized to the cytoplasm and functions as a tumor suppressor involved in regulation of cell cycle progression, intracellular trafficking, and protein turnover. RHOBTB2 Antibody is used in research settings to study loss of tumor suppressor signaling and altered cellular regulation associated with malignant transformation.
Deleted in breast cancer gene 2 is encoded by the RHOBTB2 gene and differs from classical Rho GTPases in that it lacks intrinsic GTPase activity. Instead, RHOBTB2 acts as an adaptor protein containing BTB domains that mediate interactions with Cullin 3-based E3 ubiquitin ligase complexes. Through these interactions, Deleted in breast cancer gene 2 contributes to ubiquitin-dependent protein degradation pathways that influence cell proliferation, apoptosis, and cytoskeletal organization. RHOBTB2 Antibody therefore supports investigation of ubiquitin signaling and proteostasis mechanisms in normal and disease contexts.
RHOBTB2 expression has been reported in a range of epithelial and mesenchymal tissues, with reduced expression or genetic loss observed in multiple cancer types including breast carcinoma. Decreased Deleted in breast cancer gene 2 expression has been associated with enhanced cellular proliferation, impaired apoptotic signaling, and increased migratory behavior, reinforcing its role as a tumor suppressor. RHOBTB2 Antibody enables evaluation of expression patterns relevant to cancer biology and tumor progression research.
Beyond oncology, RHOBTB2 has also been implicated in neurological and developmental processes, broadening its relevance to cell biology and disease modeling studies. RHOBTB2 Antibody provides a useful reagent for examining cytoplasmic localization and relative expression of Deleted in breast cancer gene 2 in experimental systems. Clone DBC2/12581 is designed to recognize RHOBTB2 protein and may be applied to studies focused on tumor suppression, intracellular signaling, and ubiquitin-mediated regulatory pathways.
Optimal dilution of the RHOBTB2/Deleted in breast cancer gene 2 antibody should be determined by the researcher.
A human recombinant RHOBTB2 protein fragment (around amino acids 500-700) (exact sequence is proprietary) was used as the immunogen for the RHOBTB2/Deleted in breast cancer gene 2 antibody.
RHOBTB2/Deleted in breast cancer gene 2 antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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