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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
RHOBTB2 Antibody / Tumor Suppressor Marker [clone DBC2/3361] (V9500)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9500-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V9500-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9500SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | DBC2/3361 |
| Purity | Protein A/G affinity |
| UniProt | Q9BYZ6 |
| Localization | Secreted in plasma |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This RHOBTB2 Antibody / Tumor Suppressor Marker is available for research use only. |
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Rho-related BTB domain-containing protein 2 (RHOBTB2), also known as DBC2, is an atypical Rho family regulatory protein involved in tumor suppressor signaling, cytoskeletal regulation, and ubiquitin-associated cellular control pathways. RHOBTB2 Antibody / Tumor Suppressor Marker clone DBC2/3361 is suitable for investigations involving cancer-associated signaling pathways, epithelial tumor biology, and cell regulatory mechanisms linked to proliferation and differentiation control. RHOBTB2 belongs to the atypical Rho GTPase family and contains BTB domains associated with protein-protein interactions and ubiquitination-associated regulatory signaling.
RHOBTB2 antibody, also referred to as DBC2 antibody, Rho-related BTB domain-containing protein 2 antibody, Tumor suppressor protein DBC2 antibody, and Atypical Rho GTPase antibody in the literature, recognizes a regulatory protein implicated in tumor suppressor-associated signaling pathways and cellular growth regulation. RHOBTB2 expression has been associated with epithelial tissue biology, vesicle trafficking-associated signaling, and cytoskeletal regulatory mechanisms. Through participation in ubiquitin-associated cellular pathways and intracellular signaling regulation, RHOBTB2 contributes to maintenance of cellular homeostasis and proliferation-associated control mechanisms.
Atypical Rho family proteins participate in pathways controlling cytoskeletal organization, intracellular trafficking, cellular morphology, and tumor-associated signaling networks. RHOBTB2 has attracted substantial interest in oncology research because altered RHOBTB2-associated signaling has been linked to tumor progression, epithelial malignancy biology, and dysregulated proliferation-associated pathways. DBC2 was originally identified in association with tumor suppressor-related signaling mechanisms, and subsequent studies have explored its role in cancer-associated regulatory networks and epithelial differentiation-associated biology.
RHOBTB2 additionally interacts with Cullin-associated ubiquitination pathways and cellular degradation-associated signaling mechanisms. Through regulation of intracellular trafficking and protein turnover-associated pathways, RHOBTB2 contributes to broader cellular regulatory environments influencing proliferation, differentiation, and tumor-associated signaling responses. Because atypical Rho GTPases influence multiple interconnected signaling systems, RHOBTB2 remains relevant for investigations involving epithelial tumor biology, cell cycle-associated regulation, and oncogenic signaling environments.
Immunohistochemistry analysis supports detection of endogenous RHOBTB2 expression in human renal oncocytoma and thyroid tissue, consistent with the expected expression profile of this tumor suppressor-associated regulatory protein. HuProt(TM) protein microarray specificity validation with clone DBC2/3361 further demonstrates selective recognition of RHOBTB2 among thousands of human proteins. The combined validation profile supports use of this mouse monoclonal antibody for investigations involving tumor suppressor signaling, atypical Rho GTPase biology, epithelial cancer pathways, and oncology-associated cellular regulation.
An antibody targeting RHOBTB2 can therefore support studies involving tumor suppressor-associated signaling pathways, epithelial cancer biology, atypical Rho family regulatory proteins, ubiquitination-associated cellular regulation, and oncogenic signaling-associated cellular mechanisms.
RHOBTB2 participates in tumor suppressor signaling and epithelial cancer-associated regulatory pathways; explore related oncology and signaling proteins on our Cancer Antibodies page.
Optimal dilution of the RHOBTB2 Antibody / Tumor Suppressor Marker should be determined by the researcher.
A portin of amino acids 554-604 from the human protein was used as the immunogen for the RHOBTB2 antibody.
Aliquot the RHOBTB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
RHOBTB2 antibody, DBC2 antibody, Rho-related BTB domain-containing protein 2 antibody, Tumor suppressor protein DBC2 antibody, Atypical Rho GTPase antibody
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