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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Regulator of G-protein signaling 14 is a protein that in humans is encoded by the RGS14 gene. This gene encodes a member of the regulator of G-protein signaling family. By genomic sequence analysis, this gene is mapped to chromosome 5q35.3. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein(GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.
The stated application concentrations are suggested starting amounts. Titration of the RGS14 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the C-terminus of human Regulator of G-protein signaling 14 (CTVLADQEVRLENR) was used as the immunogen for this RGS14 antibody (100% homologous in human, mouse and rat).
After reconstitution, the RGS14 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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