- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Renin receptor Antibody / ATP6AP2 (FY13351)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY13351 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
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Renin receptor antibody detects the (Pro)renin receptor, also known as ATP6AP2, a multifunctional membrane protein encoded by the ATP6AP2 gene on chromosome Xp11.4. ATP6AP2 serves dual roles as a receptor for renin and prorenin and as an accessory subunit of the vacuolar H?-ATPase (V-ATPase) complex. It is a type I transmembrane protein expressed in kidney, heart, brain, and vascular tissues, where it regulates blood pressure, renal physiology, and cellular acidification. ATP6AP2 plays crucial roles in the reninangiotensin system (RAS) and lysosomal proton pump function.
Functionally, ATP6AP2 binds both renin and its precursor prorenin, enhancing angiotensin I generation and activating intracellular signaling pathways independent of angiotensin II. This binding promotes cell proliferation, fibrosis, and inflammation through ERK1/2 and MAPK activation. In the kidney, ATP6AP2 is localized to juxtaglomerular and distal tubular cells, where it regulates renin signaling and fluid balance. As a V-ATPase accessory subunit, it stabilizes proton pump assembly, contributing to lysosomal acidification and endosomal trafficking.
Structurally, ATP6AP2 contains an extracellular renin-binding domain, a single transmembrane segment, and a short cytoplasmic tail that mediates interactions with the V-ATPase complex. It is classified within the V-ATPase assembly factor family, sharing homology with ATP6AP1. Co-localization studies show ATP6AP2 at the plasma membrane, endosomes, and lysosomes, reflecting its multifunctional localization and dual biological roles. Known interaction partners include renin, prorenin, and the V-ATPase V0 domain subunits.
ATP6AP2 is widely expressed in cardiovascular and neural tissues, with developmental expression detected in embryonic heart and brain, suggesting roles in organogenesis. In the central nervous system, ATP6AP2 modulates neuronal development, synaptic transmission, and autophagy regulation. Dysregulation of ATP6AP2 expression or mutation causes X-linked intellectual disability and Parkinsonism with spasticity (ATP6AP2-related disorder). In vascular smooth muscle and cardiac fibroblasts, ATP6AP2 signaling contributes to hypertension, cardiac hypertrophy, and fibrosis through MAPK and TGF-beta activation.
Clinically, elevated ATP6AP2 expression is associated with cardiovascular diseases, diabetic nephropathy, and tumor progression. It influences Wnt and Notch signaling pathways that regulate proliferation and differentiation. Pathway associations include reninangiotensin signaling, proton transport via V-ATPase, and lysosomal degradation. Tissue-specific studies show high ATP6AP2 activity in renal epithelia and cardiomyocytes, coordinating hormonal and metabolic regulation.
Immunohistochemical staining using Renin receptor antibody reveals membrane and cytoplasmic localization in kidney and cardiac tissues. The Renin receptor antibody from NSJ Bioreagents is an excellent reagent for research into RAS signaling, proton pump function, and cardiovascular disease mechanisms.
Optimal dilution of the Renin receptor antibody should be determined by the researcher.
A synthetic peptide corresponding to a sequence at the C-terminus of human Renin receptor/ATP6AP2 was used as the immunogen for the Renin receptor antibody.
After reconstitution, the Renin receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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