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Home >> Antibodies >> Renalase Antibody [Discontinued]

Renalase Antibody [Discontinued] [clone RNLS/1940] (V3904)

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  Catalog No Formulation Size Price (USD)  
Image V3904-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V3904-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V3904SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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IHC testing of FFPE human kidney with Renalase antibody (clone RNLS/1940). HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
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IHC testing of FFPE human kidney with Renalase antibody (clone RNLS/1940). HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
IHC testing of FFPE human kidney with Renalase antibody (clone RNLS/1940). HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
Availability Discontinued
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2b, kappa
Clone Name RNLS/1940
Purity Protein G affinity
UniProt Q5VYX0
Localization Secreted
Applications ELISA (order BSA/sodium azide-free format for coating) :
Limitations This Renalase antibody is available for research use only.
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Description

Renalase is a 342 amino acid FAD-dependent amine oxidase that is highly expressed in kidney and is expressed at a lower level in heart, skeletal muscle and small intestine. Renalase is secreted in the blood by the kidney and it is thought to regulate cardiac function and systemic blood pressure. It is also suggested that Renalase functions as a hormone that metabolizes circulating catecholamines, which have an active role in the sympathetic and parasympathetic nervous systems. Individuals with chronic kidney disease and end-stage renal disease have markedly reduced levels of plasma Renalase than healthy individuals. Infusion of Renalase in animal models causes decrease in heart rate, cardiac contractility and blood pressure. Two isoforms of Renalase exist due to alternative splicing events.

Application Notes

Optimal dilution of the Renalase antibody should be determined by the researcher.

Immunogen

A portion of amino acids 34-235 from the human protein was used as the immunogen for the Renalase antibody.

Storage

Store the Renalase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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