- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
REM2 Antibody / Rad and Gem-like GTP-binding protein 2 (FY12503)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
FY12503 | Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml | 100 ug | 439 |
REM2 antibody detects Ras-related protein REM2, a small GTP-binding protein belonging to the RGK (Rad, Gem, Kir, and Rem) family of Ras-like GTPases. REM2 regulates calcium channel activity, cytoskeletal organization, and neuronal development. Unlike classical Ras proteins, REM2 lacks membrane-targeting motifs and is primarily cytosolic. The REM2 antibody is used in neuroscience and signaling research to study calcium regulation, neuronal differentiation, and small GTPase function.
REM2 is encoded by the REM2 gene on human chromosome 14q23.2. The protein is approximately 36 kilodaltons and shares structural similarity with other RGK family members. It acts as a potent inhibitor of voltage-dependent calcium channels by binding to beta subunits, reducing calcium influx in excitable cells. This activity modulates neuronal excitability and synaptic plasticity, linking REM2 expression to learning and memory processes.
The REM2 antibody detects a 3638 kilodalton protein by western blot and exhibits cytoplasmic staining in neurons, muscle cells, and other excitable tissues. REM2 expression is dynamically regulated by neuronal activity and signaling pathways involving calcium/calmodulin-dependent kinases and cAMP response element-binding protein (CREB). Overexpression of REM2 suppresses calcium current density, alters actin filament organization, and inhibits dendritic spine formation. Conversely, its downregulation promotes neurite outgrowth and synaptic connectivity.
Beyond neuronal contexts, REM2 contributes to cytoskeletal remodeling and cell proliferation. It interacts with 14-3-3 proteins and signaling kinases, coordinating calcium-dependent gene expression and structural plasticity. Dysregulation of REM2 has been associated with mood disorders, neuropathic pain, and cardiac remodeling. NSJ Bioreagents provides a validated REM2 antibody optimized for western blot, immunofluorescence, and neuronal imaging applications, supporting detailed analysis of GTPase-mediated calcium signaling and neuronal differentiation.
Optimal dilution of the REM2 antibody should be determined by the researcher.
E.coli-derived human REM2 recombinant protein (Position: R65-E257) was used as the immunogen for the REM2 antibody.
After reconstitution, the REM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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