- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ZAP70 Antibody / Immunological Synapse Signaling Antibody [clone ZAP70/6492R] (V9598)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9598-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V9598-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9598SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | ZAP70/6492R |
| Purity | Protein A/G affinity |
| UniProt | P43403 |
| Localization | Cell surface and cytoplasm |
| Applications | ELISA (Use Ab At 2-4ug/ml For Coating) (Order Ab Without BSA) : Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This ZAP70 antibody is available for research use only. |
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Zeta-chain-associated protein kinase 70 (ZAP70) is a cytoplasmic tyrosine kinase that plays a critical role in signaling at the immunological synapse, the specialized junction formed between T cells and antigen-presenting cells during immune recognition. ZAP70 Antibody is uniquely positioned for studying immunological synapse signaling, where spatial organization of receptors and signaling molecules governs T-cell activation. ZAP70 antibody, also referred to as Zeta-chain-associated protein kinase 70 antibody or ZAP-70 antibody in the literature, is widely used to investigate signaling events that occur at this highly structured cell-cell interface.
The immunological synapse is characterized by clustering of T-cell receptors and associated signaling proteins into organized domains that facilitate efficient signal transmission. ZAP70 is rapidly recruited to the T-cell receptor complex within this synapse following antigen engagement, where it becomes activated and initiates downstream signaling cascades. This localized activation is essential for coordinating signaling events that drive T-cell activation, proliferation, and effector function. Unlike diffuse cytoplasmic signaling, synapse-associated signaling is spatially restricted and highly regulated.
This ZAP70 Antibody is uniquely positioned for studying signaling within the immunological synapse, emphasizing spatial organization, receptor clustering, and membrane-associated signaling complexes rather than general intracellular signaling pathways. Its use supports investigation of how signaling molecules are recruited to and organized within the synapse, and how these structures influence signaling strength and duration. This differentiator clearly separates it from receptor signaling pages that focus on molecular initiation and from signal transduction pages that emphasize downstream pathway propagation.
ZAP70 activity at the immunological synapse is closely linked to cytoskeletal rearrangements and membrane dynamics that stabilize cell-cell interactions. These processes enable sustained signaling and effective communication between immune cells. Studying ZAP70 in this context provides insight into how immune cells coordinate signaling in space and time to generate appropriate responses to antigenic stimulation.
In experimental systems, immunological synapse formation can be modeled using T cells interacting with antigen-presenting cells or artificial surfaces presenting activating ligands. ZAP70 serves as a key marker for analyzing synapse formation and signaling dynamics in these models. Its recruitment and activation within the synapse provide a direct readout of functional receptor engagement.
Overall, ZAP70 Antibody provides a specialized tool for investigating immunological synapse signaling, enabling detailed study of spatially organized signaling events, receptor clustering, and cell-cell communication processes that define T-cell activation at the interface between immune cells.
Optimal dilution of the ZAP70 Antibody / Immunological Synapse Signaling Antibody should be determined by the researcher.
A portion of amino acids 247-382 was used as the immunogen for the ZAP70 Antibody / Immunological Synapse Signaling Antibody.
Aliquot the recombinant ZAP70 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
ZAP70 antibody, Zeta-chain-associated protein kinase 70 antibody, ZAP70 immune synapse antibody, ZAP70 T-cell synapse signaling antibody, ZAP70 cell-cell interaction antibody
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