- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
von Willebrand Factor Antibody / Angiogenesis Marker Antibody. [clone VWF/4384R] (V9636)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9636-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V9636-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9636SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | VWF/4384R |
| Purity | Protein A/G affinity |
| UniProt | P04275 |
| Localization | Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This recombinant von Willebrand Factor antibody is available for research use only. |
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Von Willebrand factor (VWF) is a secreted glycoprotein encoded by the VWF gene and produced primarily by vascular endothelial cells and megakaryocytes. von Willebrand Factor Antibody / Angiogenesis Marker Antibody recognizes a protein that is strongly associated with endothelial cells, making it highly relevant for studies of new blood vessel formation. VWF antibody, also referred to as von Willebrand factor antibody or factor VIII-related antigen antibody, is widely used to visualize endothelial cells in contexts where vascular growth, remodeling, and expansion are actively occurring.
Angiogenesis is a dynamic biological process involving endothelial cell activation, proliferation, migration, and organization into new vascular structures. During this process, endothelial cells form sprouting vessels, branching networks, and newly perfused channels that support tissue growth and repair. Because VWF is consistently expressed within endothelial cells, it provides a reliable signal for identifying these newly formed vascular elements. von Willebrand Factor Antibody is therefore particularly useful for detecting areas of active vessel formation and assessing how endothelial cells contribute to evolving vascular architecture.
At the subcellular level, VWF is localized to Weibel-Palade bodies within endothelial cells, specialized secretory organelles that store the protein prior to regulated release. In angiogenic settings, endothelial activation is often accompanied by changes in these storage and secretion pathways, reflecting the functional state of the cells. Although VWF participates in hemostasis through platelet adhesion and factor VIII stabilization, its consistent presence in endothelial cells makes it especially valuable as a structural readout of vascular expansion rather than as a marker of coagulation alone.
In tissues undergoing angiogenesis, vascular patterns often shift dramatically, with increases in microvessel density, branching complexity, and regional heterogeneity. von Willebrand Factor Antibody supports analysis of these changes by highlighting endothelial-lined structures across both established vessels and newly formed capillary networks. This enables researchers to visualize how vascular growth integrates into surrounding tissue, whether in regenerating organs, inflamed regions, or developing systems.
Angiogenesis is a defining feature of many pathological conditions, including tumor progression, chronic inflammation, and ischemic injury. In tumors, for example, new vessel formation supports nutrient delivery and contributes to the structural organization of the tumor microenvironment. In regenerative contexts, angiogenesis is essential for restoring tissue viability and function. VWF expression remains closely linked to endothelial identity in these settings, allowing it to serve as a dependable marker for identifying vascular components within actively remodeling tissue.
von Willebrand Factor Antibody / Angiogenesis Marker Antibody is therefore particularly well suited for studies focused on vascular growth and endothelial dynamics. By highlighting endothelial cells within newly formed and expanding vessels, it supports detailed examination of angiogenic processes, including vessel sprouting, network formation, and structural adaptation across a wide range of biological and disease models.
Optimal dilution of the von Willebrand Factor Antibody / Angiogenesis Marker Antibody. should be determined by the researcher.
A portion of amino acids 1150-1250 was used as the immunogen for the von Willebrand Factor Antibody / Angiogenesis Marker Antibody.
Aliquot the recombinant von Willebrand Factor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
VWF angiogenesis antibody, von Willebrand factor vascular growth antibody, endothelial sprouting marker antibody, neovascular marker antibody, VWF vessel formation antibody
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