- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TTF-1 Antibody / Lung Adenocarcinoma Marker Antibody [clone rNX2.1/690] (V3654)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V3654-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3654-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3654SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 | |
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V3654IHC-7ML | Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* | 7 ml | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Purified |
| Host | Mouse |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rNX2.1/690 |
| Purity | Protein G affinity chromatography |
| UniProt | P43699 |
| Localization | Nuclear |
| Applications | Immunohistochemistry (FFPE) : 0.5-1ug/ml for 30 min at RT |
| Limitations | This TTF-1 antibody is available for research use only. |
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Thyroid transcription factor 1 (NKX2-1) is a nuclear homeobox transcription factor that regulates epithelial lineage development in the lung, thyroid, and forebrain. The protein belongs to the NKX2 family of transcriptional regulators and functions as a DNA-binding factor controlling genes involved in pulmonary epithelial differentiation and lung development. The TTF-1 Antibody / Lung Adenocarcinoma Marker Antibody targets this lineage-defining nuclear transcription factor, which is normally expressed in alveolar epithelial cells and bronchiolar epithelium of the respiratory tract.
In diagnostic pathology, TTF-1 antibody staining is strongly associated with pulmonary epithelial lineage and is widely used as a lung adenocarcinoma marker in immunohistochemistry. Nuclear TTF-1 expression is frequently observed in primary pulmonary adenocarcinoma and small cell lung carcinoma, while many non-pulmonary tumors lack expression. Because of this pattern, TTF-1 antibody staining is routinely used to identify lung tumor origin and to distinguish primary pulmonary adenocarcinoma from metastatic carcinomas involving the lung. Clone rNX2.1/690 antibody is a recombinant mouse monoclonal antibody designed to detect nuclear NKX2-1 protein in pulmonary epithelial cells and lung tumors.
TTF-1 antibody, also referred to as NKX2-1 antibody or Thyroid transcription factor 1 antibody in the literature, recognizes a transcription factor that controls pulmonary epithelial gene expression and respiratory lineage identity. NKX2-1 regulates several lung-specific genes, including surfactant proteins and other molecules required for respiratory epithelial function. During embryonic development the transcription factor plays a central role in lung bud formation and respiratory epithelial differentiation, establishing NKX2-1 as a key regulator of pulmonary epithelial lineage.
In surgical pathology laboratories, TTF-1 antibody is commonly incorporated into immunohistochemical tumor panels used for lung cancer classification. Strong nuclear staining in tumor cells supports pulmonary adenocarcinoma origin and assists pathologists in differentiating lung tumors from metastatic carcinomas arising from organs such as the gastrointestinal tract, breast, or kidney. For this reason, TTF-1 antibody is frequently used together with markers such as Napsin A, cytokeratins, and other epithelial lineage markers to improve diagnostic accuracy when evaluating lung carcinoma specimens.
Because of its consistent nuclear localization in pulmonary epithelial cells, NKX2-1 remains one of the most widely used transcription factor markers in lung cancer immunohistochemistry. A TTF-1 antibody such as clone rNX2.1/690 supports research focused on pulmonary epithelial biology, lung adenocarcinoma development, and transcriptional control of respiratory epithelial differentiation. The antibody therefore provides a valuable tool for studies investigating lung tumor pathology, pulmonary lineage determination, and molecular mechanisms governing lung epithelial identity.
Optimal dilution of the TTF-1 Antibody / Lung Adenocarcinoma Marker Antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Recombinant protein was used as the immunogen for the recombinant TTF-1 antibody.
Store the TTF-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
NKX2-1 antibody, Thyroid transcription factor 1 antibody, TTF1 antibody, TTF1 lung marker antibody, Thyroid transcription factor antibody
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