- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Tripartite motif-containing protein 29 Antibody / TRIM29 [clone TRIM29/9257R] (V5598)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5598-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V5598-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V5598SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | TRIM29/9257R |
| Purity | Protein A/G affinity |
| UniProt | Q14134 |
| Localization | Cytoplasm, Cell membrane |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Tripartite motif-containing protein 29 antibody is available for research use only. |
|
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Tripartite motif-containing protein 29 is a member of the TRIM protein family encoded by the TRIM29 gene and is also known as ATDC or ataxia-telangiectasia group D complementing protein. The Tripartite motif-containing protein 29 Antibody is developed to detect this epithelial-associated regulatory protein in research applications focused on stress signaling and tumor biology. Clone TRIM29/9257R is a recombinant rabbit monoclonal antibody designed for specific recognition of TRIM29 expression in cellular and tissue-based studies. TRIM29 is located on chromosome 11q23 and, unlike many other TRIM family members, lacks a canonical RING domain while retaining B-box and coiled-coil motifs that mediate protein-protein interactions.
TRIM29 functions primarily as a scaffold-like regulatory protein and has been implicated in modulation of DNA damage response pathways, chromatin organization, and transcriptional regulation. It interacts with components of the p53 signaling axis and other regulatory complexes involved in cellular responses to genotoxic stress. Through these interactions, TRIM29 influences cell proliferation, apoptosis, and epithelial differentiation. Subcellular localization studies describe both cytoplasmic and nuclear distribution, depending on tissue type and physiologic context.
Expression of TRIM29 is enriched in epithelial tissues including pancreas, lung, skin, and gastrointestinal tract. In cancer research, altered TRIM29 expression has been documented in pancreatic, gastric, lung, breast, and bladder carcinomas. Its biologic role appears context dependent, with studies suggesting involvement in tumor progression, invasion, or modulation of stress response pathways depending on tumor type. This dual behavior underscores its importance in epithelial transformation and oncogenic signaling networks.
As part of the broader tripartite motif protein family, TRIM29 contributes to cellular pathways that regulate protein stability and stress adaptation. Investigation of TRIM29 expression supports research focused on epithelial integrity, DNA damage response mechanisms, and cancer-associated signaling biology.
Optimal dilution of the Tripartite motif-containing protein 29 antibody should be determined by the researcher.
A recombinant fragment (within amino acids 1-200) of human recombinant Tripartite motif-containing protein 29 protein was used as the immunogen for the TRIM29 antibody.
Aliquot the Tripartite motif-containing protein 29 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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