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It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.
Optimal dilution of the recombinant Transferrin Receptor antibody should be determined by the researcher.
Recombinant human fragment (within amino acids 50-250) of human TFRC/CD71 protein was used as the immunogen for the recombinant Transferrin Receptor antibody.
Aliquot the recombinant Transferrin Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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