- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Recombinant TPSAB1 Antibody / Tryptase [clone rTPSAB1/1963] (V4428)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4428-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 539 | |
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V4428-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 249 | |
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V4428SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Recombinant Mouse Monoclonal |
| Isotype | Mouse IgG1, kappa |
| Clone Name | rTPSAB1/1963 |
| Purity | Protein A/G affinity |
| UniProt | Q15661 |
| Localization | Secreted, Cytoplasm |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This recombinant TPSAB1 antibody is available for research use only. |
|
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Recombinant TPSAB1 antibody detects Tryptase 1, a serine protease encoded by the TPSAB1 gene and abundantly expressed in mast cells. The UniProt recommended name is Tryptase alpha/beta-1 (TPSAB1). This enzyme represents a dominant effector molecule of mast cell activation, where it contributes to allergic inflammation, vascular regulation, and immune cell recruitment.
Tryptase 1 functions as a secreted tetrameric enzyme that depends on heparin for structural stability and enzymatic activity. Upon degranulation, mast cells release large quantities of tryptase into surrounding tissues, where it acts on extracellular matrix components, cytokines, and cell surface receptors. Through activation of protease-activated receptor 2 (PAR-2), tryptase triggers pro-inflammatory and tissue remodeling cascades that are hallmarks of allergic and fibrotic disease. It also influences wound healing and angiogenesis by modulating fibroblast and endothelial cell behavior.
The TPSAB1 gene resides on chromosome 16p13.3 within a tryptase gene cluster that includes TPSB2 and TPSG1. Its transcription is largely restricted to mast cells and basophils, where it supports granule maturation and regulated exocytosis. Both alpha and beta isoforms are produced, differing in catalytic stability but sharing similar biological functions. These isoforms contribute to interindividual variability in allergic sensitivity and baseline serum tryptase concentrations.
Clinically, TPSAB1 activity serves as a marker of mast cell activation. Elevated tryptase levels are characteristic of anaphylaxis, mastocytosis, and chronic allergic inflammation. Copy number variation of TPSAB1 underlies hereditary alpha-tryptasemia, a genetic condition associated with elevated serum tryptase and connective tissue symptoms. Research using Recombinant TPSAB1 antibody supports studies of mast cell degranulation, serine protease signaling, and inflammatory pathology.
Recombinant TPSAB1 antibody is designed for research use in detecting Tryptase 1 expression and investigating mast cellârelated pathways. NSJ Bioreagents offers this antibody for use in allergy, immunology, and tissue remodeling research where precise detection of mast cell proteases is required.
Optimal dilution of the recombinant TPSAB1 antibody should be determined by the researcher.
A portion of amino acids 115-233 from the human protein was used as the immunogen for this recombinant TPSAB1 antibody.
Aliquot the recombinant TPSAB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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